HitPredict

Interactor 1: RPN5 (Q12250)
26S proteasome regulatory subunit RPN5 (Proteasome non-ATPase subunit 5)
Gene: RPN5

Interactor 2: RPN6 (Q12377)
26S proteasome regulatory subunit RPN6 (Proteasome non-ATPase subunit 4)
Gene: RPN6

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.988

Property	Details
Experiments	11742986, 11805837, 11805826, 15102831, 15611133, 26451487, 25919710, 16869714, 31848235, 21289098, 22195964, 19446322, 23911091, 24412063, 9741626, 10873636, 16554755, 16429126, 37968396, 14759368 and 1 others more... 18467557
Identification Methods	two hybrid, anti tag coimmunoprecipitation, tandem affinity purification, affinity chromatography technology, biochemical, protein complementation assay, cross-linking study, dihydrofolate reductase reconstruction
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PCI~PCI, PCI~PSMD12-CSN4_N
Common GO terms	GO:0000502 - proteasome complex GO:0008541 - proteasome regulatory particle, lid subcomplex GO:0034515 - proteasome storage granule GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 445 Sc			1 434
+	Hs
		127824 PSD12_HUMAN (7-443): 3.18e-131: 387: 40.45		PSD11_HUMAN (1-433): 4.62e-98: 301: 41.01
+	Dm
		1267338 Q9V3Z4_DROME (8-442): 1.09e-114: 347: 31.21		PSD11_DROME (3-433): 1.12e-99: 306: 44.44
+	Hs
		128232 PSD12_HUMAN (7-443): 3.18e-131: 387: 40.45		PSMD6_HUMAN (65-432): 1.67e-73: 237: 13.78
+	Zm
		6840 A0A1D6E9U1_MAIZE (9-435): 1.31e-95: 296: 13.79		A0A1D6E9U1_MAIZE (11-433): 7.72e-100: 306: 40.42
+	Hs
		127919 CSN2_HUMAN (17-426): 1.58e-95: 296: 13.27		PSD11_HUMAN (1-433): 4.62e-98: 301: 41.01
+	Dm
		1267330 CSN2_DROME (2-426): 3.75e-91: 285: 13.01		PSD11_DROME (3-433): 1.12e-99: 306: 44.44
+	Hs
		127823 PSD11_HUMAN (20-435): 2.55e-93: 289: 12.68		PSD11_HUMAN (1-433): 4.62e-98: 301: 41.01
+	Hs
		958615 CSN2_HUMAN (17-426): 1.58e-95: 296: 13.27		CSN2_HUMAN (7-431): 4.92e-93: 289: 19.95
+	Dm
		1463473 Q9V3Z4_DROME (8-442): 1.09e-114: 347: 31.21		PSMD6_DROME (53-432): 3.19e-69: 226: 13.35
+	Dm
		1375260 CSN2_DROME (2-426): 3.75e-91: 285: 13.01		CSN2_DROME (8-431): 4.7e-88: 276: 17.89
+	At
		852148 CSN2_ARATH (2-428): 1.28e-101: 311: 14.81		CSN1_ARATH (41-433): 5.19e-71: 232: 14.53
+	An
		1202929 CSN2_EMENI (1-425): 1.18e-94: 295: 12.11		CSN2_EMENI (9-424): 3.05e-76: 247: 17.14
+	Mm
		107991 CSN2_MOUSE (17-426): 1.58e-95: 296: 13.27		G3UXW9_MOUSE (46-433): 5.37e-72: 237: 12.32
+	Hs
		127964 PSD11_HUMAN (20-435): 2.55e-93: 289: 12.68		PSMD6_HUMAN (65-432): 1.67e-73: 237: 13.78
+	Hs
		958628 CSN2_HUMAN (17-426): 1.58e-95: 296: 13.27		CSN1_HUMAN (41-433): 1.28e-68: 227: 12.07
+	Mm
		312554 CSN2_MOUSE (17-426): 1.58e-95: 296: 13.27		CSN4_MOUSE (58-430): 6.18e-65: 215: 15.50
+	Hs
		958704 CSN2_HUMAN (17-426): 1.58e-95: 296: 13.27		CSN4_HUMAN (58-430): 4.64e-65: 215: 15.25
+	An
		1202931 CSN2_EMENI (1-425): 1.18e-94: 295: 12.11		CSN1_EMENI (215-433): 6.39e-24: 105: 12.17
+	Dm
		1375262 CSN2_DROME (2-426): 3.75e-91: 285: 13.01		CSN4_DROME (137-426): 9.92e-19: 89.5: 15.56