HitPredict

Interactor 1: NMDE1 (Q12879)
Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A)
Gene: GRIN2A

Interactor 2: NMDE2 (Q13224)
Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3)
Gene: GRIN2B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.79 1.00 0.890

The method score is based on:

Property Details
Experiments 14529713, 8139656, 15888440, 33961781
Identification Methods affinity chromatography technology, fluorescent resonance energy transfer, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains ANF_receptor~ANF_receptor, ANF_receptor~Lig_chan, ANF_receptor~Lig_chan-Glu_bd, Lig_chan~Lig_chan, Lig_chan~Lig_chan-Glu_bd, Lig_chan-Glu_bd~Lig_chan-Glu_bd
Common GO terms GO:0001540 - amyloid-beta binding
GO:0004972 - NMDA glutamate receptor activity
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0007215 - glutamate receptor signaling pathway
and 25 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 1464
Hs

1 1484
+ Mm
+ Rn
+ Hs
+ Rn
+ Hs
+ Mm
+ Mm
+ Mm
+ Mm
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Xl
+ Hs
+ Rn
+ Mm

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Last updated: 11Aug2025