HitPredict

Interactor 1: NMDZ1 (Q05586)
Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1) (hNR1)
Gene: GRIN1

Interactor 2: NMDE2 (Q13224)
Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3)
Gene: GRIN2B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.969

The method score is based on:

Property Details
Experiments 19811606, 17459877, 14529713, 19487695, 15888440, 23621516, 12391275, 18233995, 8139656, 34321660
Identification Methods affinity chromatography technology, pull down, fluorescent resonance energy transfer, electron microscopy 3D single particle reconstruction, molecular sieving
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains ANF_receptor~ANF_receptor, ANF_receptor~Lig_chan, ANF_receptor~Lig_chan-Glu_bd, Lig_chan~Lig_chan, Lig_chan~Lig_chan-Glu_bd, Lig_chan-Glu_bd~Lig_chan-Glu_bd
Common GO terms GO:0001540 - amyloid-beta binding
GO:0004972 - NMDA glutamate receptor activity
GO:0005737 - cytoplasm
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
and 25 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 938
Hs

1 1484
+ Rn
+ Mm
+ Xl
+ Mm
+ Rn
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Rn
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025