HitPredict

Interactor 1: CUL3 (Q17391)
Cullin-3 (CUL-3)
Gene: cul-3

Interactor 2: NEDD8 (Q93725)
NEDD8 (Neddylin) (Protein NED-8) (Ubiquitin-like protein Nedd8)
Gene: ned-8

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	12781129, 17403899
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cullin~ubiquitin, Cullin_Nedd8~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 777 Ce			1 77
+	Hs
		1041658 CUL3_HUMAN (1-777): 0: 849: 47.95		NEDD8_HUMAN (1-76): 1.05e-37: 122: 88.16
+	Hs
		923983 CUL3_HUMAN (1-777): 0: 849: 47.95		RS27A_HUMAN (1-76): 5.06e-36: 120: 61.84
+	Dm
		1213846 Q8IP45_DROME (16-777): 0: 827: 47.65		NEDD8_DROME (1-76): 1.25e-34: 114: 89.47
+	At
		1352191 CUL3A_ARATH (7-777): 0: 817: 40.62		RUB1_ARATH (2-77): 5.16e-27: 97.5: 80.26
+	Hs
		1043010 CUL4A_HUMAN (10-777): 0: 790: 33.68		NEDD8_HUMAN (1-76): 1.05e-37: 122: 88.16
+	Hs
		923984 CUL4A_HUMAN (10-777): 0: 790: 33.68		RS27A_HUMAN (1-76): 5.06e-36: 120: 61.84
+	Hs
		1043371 CUL4B_HUMAN (5-777): 0: 785: 34.11		NEDD8_HUMAN (1-76): 1.05e-37: 122: 88.16
+	Hs
		923985 CUL4B_HUMAN (5-777): 0: 785: 34.11		RS27A_HUMAN (1-76): 5.06e-36: 120: 61.84
+	Hs
		924296 CUL4A_HUMAN (10-777): 0: 790: 33.68		RL40_HUMAN (1-76): 9.86e-34: 113: 61.84
+	At
		1321116 CUL3B_ARATH (7-777): 0: 801: 40.75		RUB1_ARATH (2-77): 5.16e-27: 97.5: 80.26
+	Hs
		475024 CUL4B_HUMAN (5-777): 0: 785: 34.11		UBB_HUMAN (1-76): 1.2e-30: 108: 61.84
+	Hs
		1041004 CUL1_HUMAN (19-777): 0: 696: 27.15		NEDD8_HUMAN (1-76): 1.05e-37: 122: 88.16
+	At
		1277343 CUL1_ARATH (20-777): 0: 698: 25.48		RUB1_ARATH (2-77): 5.16e-27: 97.5: 80.26
+	At
		1247030 CUL1_ARATH (20-777): 0: 698: 25.48		RUB2_ARATH (2-76): 2.66e-25: 92.9: 80.00
+	Hs
		1041337 CUL2_HUMAN (17-777): 0: 662: 25.66		NEDD8_HUMAN (1-76): 1.05e-37: 122: 88.16
+	Dm
		1097203 CUL1_DROME (1-777): 0: 663: 24.37		NEDD8_DROME (1-76): 1.25e-34: 114: 89.47
+	Sp
		142907 CUL1_SCHPO (30-777): 0: 637: 27.74		UBL1_SCHPO (1-76): 1.21e-32: 109: 82.90
+	Sp
		145590 CUL3_SCHPO (8-777): 0: 630: 32.23		UBL1_SCHPO (1-76): 1.21e-32: 109: 82.90
+	Hs
		1079566 CUL5_HUMAN (27-777): 0: 554: 21.92		NEDD8_HUMAN (1-76): 1.05e-37: 122: 88.16