HitPredict

Interactor 1: TP53B (Q12888)
TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)
Gene: TP53BP1

Interactor 2: TOPB1 (Q92547)
DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1)
Gene: TOPBP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.75 0.60 0.672

The method score is based on:

Property Details
Experiments 11756551, 33503405, 31135337, 29656893
Identification Methods affinity chromatography technology, proximity labelling technology, x-ray crystallography
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000077 - DNA damage checkpoint signaling
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0006974 - DNA damage response
and 4 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 1972
Hs

1 1522
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Service provided by Combinatics, Japan

Last updated: 11Aug2025