HitPredict

Interactor 1: DLG1 (Q12959)
Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)
Gene: DLG1

Interactor 2: LIN7B (Q9HAP6)
Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2)
Gene: LIN7B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	33961781, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, L27~L27_1, PDZ~PDZ
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0005923 - bicellular tight junction GO:0016323 - basolateral plasma membrane GO:0097025 - MPP7-DLG1-LIN7 complex and 1 others more... GO:0098839 - postsynaptic density membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 904 Hs			1 207
+	Hs
		1091580 DLG1_HUMAN (1-904): 0: 706: 100.00		LIN7C_HUMAN (1-196): 2.27e-58: 183: 84.69
+	Mm
		313202 DLG1_MOUSE (1-904): 0: 700: 95.58		LIN7C_MOUSE (1-196): 2.27e-58: 183: 84.69
+	Hs
		167694 DLG1_HUMAN (1-904): 0: 706: 100.00		LIN7A_HUMAN (4-194): 5.1e-53: 171: 79.06
+	Hs
		168680 DLG1_HUMAN (1-904): 0: 706: 100.00		CSKP_HUMAN (10-206): 2.29e-30: 119: 20.49
+	Mm
		267274 DLG1_MOUSE (1-904): 0: 700: 95.58		CSKP_MOUSE (10-206): 2.38e-30: 119: 20.49
+	Hs
		1091484 DLG1_HUMAN (1-904): 0: 706: 100.00		DLG1_HUMAN (57-181): 2.16e-25: 104: 29.23
+	Hs
		1091503 DLG1_HUMAN (1-904): 0: 706: 100.00		DLG2_HUMAN (89-202): 3.42e-25: 104: 29.41
+	Mm
		1223608 DLG1_MOUSE (1-904): 0: 700: 95.58		DLG4_MOUSE (86-204): 1.67e-24: 102: 27.42
+	Rn
		1224257 DLG1_RAT (1-904): 0: 679: 92.65		CSKP_RAT (10-206): 3.2e-30: 118: 20.49
+	Hs
		1091548 DLG1_HUMAN (1-904): 0: 706: 100.00		DLG3_HUMAN (29-164): 2.22e-20: 90.3: 25.53
+	Rn
		1224262 DLG1_RAT (1-904): 0: 679: 92.65		DLG2_RAT (89-202): 3.1e-25: 104: 29.41
+	Mm
		1190725 Q3UP61_MOUSE (1-904): 0: 680: 92.49		DLG4_MOUSE (86-204): 1.67e-24: 102: 27.42
+	Rn
		723883 DLG1_RAT (1-904): 0: 679: 92.65		DLG4_RAT (86-204): 4.31e-24: 101: 27.42
+	Rn
		1224258 DLG1_RAT (1-904): 0: 679: 92.65		DLG3_RAT (56-164): 8.92e-22: 94.5: 30.70
+	Hs
		168730 DLG3_HUMAN (137-904): 0: 569: 66.11		CSKP_HUMAN (10-206): 2.29e-30: 119: 20.49
+	Mm
		999796 DLG3_MOUSE (99-904): 0: 574: 65.54		DLG2_MOUSE (89-202): 3.19e-25: 104: 29.41
+	Rn
		723886 DLG3_RAT (99-904): 0: 575: 65.42		DLG4_RAT (86-204): 4.31e-24: 101: 27.42
+	Mm
		999787 DLG3_MOUSE (99-904): 0: 574: 65.54		DLG4_MOUSE (86-204): 1.67e-24: 102: 27.42
+	Hs
		1006087 DLG3_HUMAN (137-904): 0: 569: 66.11		DLG4_HUMAN (86-204): 4.39e-24: 101: 27.42