HitPredict

Interactor 1: SRSF5 (Q13243)
Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)
Gene: SRSF5

Interactor 2: SRPK1 (Q96SB4)
SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1)
Gene: SRPK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 272 Hs			1 655
+	Hs
		1061109 SRSF1_HUMAN (2-170): 6.58e-57: 184: 43.68		SRPK1_HUMAN (1-655): 1.26e-157: 470: 94.64
+	Hs
		1006354 SRSF1_HUMAN (2-170): 6.58e-57: 184: 43.68		SRPK2_HUMAN (48-655): 2.61e-129: 398: 54.43
+	Hs
		1006372 SRSF5_HUMAN (1-240): 2.61e-54: 178: 100.00		SRPK2_HUMAN (48-655): 2.61e-129: 398: 54.43
+	Hs
		1006356 SRSF4_HUMAN (5-265): 3.79e-51: 176: 53.64		SRPK2_HUMAN (48-655): 2.61e-129: 398: 54.43
+	Hs
		1061210 SRSF1_HUMAN (2-170): 6.58e-57: 184: 43.68		SRPK3_HUMAN (29-654): 2.82e-99: 316: 38.95
+	Hs
		1099308 SRSF5_HUMAN (1-240): 2.61e-54: 178: 100.00		SRPK3_HUMAN (29-654): 2.82e-99: 316: 38.95
+	Hs
		1062154 SRSF4_HUMAN (5-265): 3.79e-51: 176: 53.64		SRPK3_HUMAN (29-654): 2.82e-99: 316: 38.95
+	Hs
		889557 SRSF1_HUMAN (2-170): 6.58e-57: 184: 43.68		CLK2_HUMAN (484-653): 2.43e-63: 220: 29.07
+	Hs
		1061160 SRSF1_HUMAN (2-170): 6.58e-57: 184: 43.68		CLK4_HUMAN (436-654): 5.53e-63: 218: 23.89
+	Hs
		1099261 SRSF5_HUMAN (1-240): 2.61e-54: 178: 100.00		CLK4_HUMAN (436-654): 5.53e-63: 218: 23.89
+	Hs
		889406 SRSF1_HUMAN (2-170): 6.58e-57: 184: 43.68		CLK1_HUMAN (436-654): 8.63e-61: 212: 23.45
+	Hs
		889558 SRSF4_HUMAN (5-265): 3.79e-51: 176: 53.64		CLK2_HUMAN (484-653): 2.43e-63: 220: 29.07
+	Hs
		889716 SRSF1_HUMAN (2-170): 6.58e-57: 184: 43.68		CLK3_HUMAN (484-653): 3.29e-60: 211: 28.65
+	Hs
		1062119 SRSF4_HUMAN (5-265): 3.79e-51: 176: 53.64		CLK4_HUMAN (436-654): 5.53e-63: 218: 23.89
+	Hs
		889413 SRSF5_HUMAN (1-240): 2.61e-54: 178: 100.00		CLK1_HUMAN (436-654): 8.63e-61: 212: 23.45
+	Hs
		889721 SRSF5_HUMAN (1-240): 2.61e-54: 178: 100.00		CLK3_HUMAN (484-653): 3.29e-60: 211: 28.65
+	Hs
		889407 SRSF4_HUMAN (5-265): 3.79e-51: 176: 53.64		CLK1_HUMAN (436-654): 8.63e-61: 212: 23.45
+	Hs
		889717 SRSF4_HUMAN (5-265): 3.79e-51: 176: 53.64		CLK3_HUMAN (484-653): 3.29e-60: 211: 28.65
+	Hs
		1099085 SRSF5_HUMAN (1-240): 2.61e-54: 178: 100.00		KS6A1_HUMAN (447-655): 5.56e-25: 112: 15.46
+	Dm
		1464675 Q9V3W7_DROME (2-190): 8.54e-55: 179: 36.27		Q9VGQ0_DROME (456-654): 5.09e-14: 77.1: 15.12