HitPredict

Interactor 1: AGAP2 (Q3UHD9)
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (Phosphatidylinositol 3-kinase enhancer) (PIKE)
Gene: AGAP2

Interactor 2: NEB2 (Q6R891)
Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)
Gene: Ppp1r9b

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	28706196, 30562941, 28634551
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PDZ~Ras
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0030036 - actin cytoskeleton organization GO:0030425 - dendrite GO:0044877 - protein-containing complex binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1186 Mm			1 817
+	Mm
		110605 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		H3BL28_MOUSE (1-817): 7.14e-94: 318: 45.27
+	Mm
		1112600 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		Q7TN74_MOUSE (1-817): 7.67e-91: 311: 45.27
+	Mm
		1112635 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		DLG2_MOUSE (85-704): 1.1e-42: 169: 13.14
+	Mm
		1112610 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		DLG1_MOUSE (244-705): 2.57e-41: 165: 15.98
+	Mm
		1112570 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		Q52KF7_MOUSE (269-734): 2.55e-41: 164: 17.38
+	Mm
		936177 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		DLG3_MOUSE (224-734): 1.59e-39: 159: 16.23
+	Mm
		1112634 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		LNX2_MOUSE (13-580): 4.46e-37: 150: 11.00
+	Mm
		1112581 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		DLG4_MOUSE (381-806): 1.83e-31: 133: 11.04
+	Mm
		88312 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		D3YUZ8_MOUSE (472-796): 3.4e-27: 120: 15.08
+	Hs
		876539 AGAP1_HUMAN (384-1145): 0: 713: 53.70		AFAD_HUMAN (397-798): 1.76e-38: 157: 18.69
+	Hs
		1300695 AGAP1_HUMAN (384-1145): 0: 713: 53.70		MAGI1_HUMAN (449-794): 5.95e-16: 84.7: 12.50
+	Hs
		1021587 ASAP1_HUMAN (746-1166): 2.43e-83: 297: 21.99		DLG1_HUMAN (80-763): 3.75e-33: 139: 11.22
+	Hs
		919668 RAP1A_HUMAN (398-567): 1.81e-70: 235: 23.03		RADIL_HUMAN (176-582): 1.35e-44: 176: 18.05
+	Hs
		876348 RAP1A_HUMAN (398-567): 1.81e-70: 235: 23.03		AFAD_HUMAN (397-798): 1.76e-38: 157: 18.69
+	Mm
		1143335 GIT1_MOUSE (932-1139): 6.25e-72: 258: 32.88		DLG4_MOUSE (381-806): 1.83e-31: 133: 11.04
+	Hs
		1020239 GIT1_HUMAN (932-1139): 4.84e-72: 258: 32.88		PTN13_HUMAN (51-808): 7.26e-17: 88.2: 9.60