HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: UBP32 (Q8NFA0)
Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32)
Gene: USP32

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:1904263 - positive regulation of TORC1 signaling
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 1604
+	Hs
		853464 CUL3_HUMAN (1-768): 0: 943: 100.00		UBP5_HUMAN (436-1068): 2.54e-79: 283: 13.04
+	Hs
		1113120 CUL3_HUMAN (1-768): 0: 943: 100.00		UBP10_HUMAN (1010-1569): 3.8e-36: 150: 13.27
+	Hs
		1114614 CUL3_HUMAN (1-768): 0: 943: 100.00		UBP21_HUMAN (718-918): 9.2e-27: 119: 32.74
+	Hs
		322936 CUL3_HUMAN (1-768): 0: 943: 100.00		UBP19_HUMAN (1339-1585): 3.61e-24: 113: 14.84
+	Hs
		1114673 CUL3_HUMAN (1-768): 0: 943: 100.00		UBP22_HUMAN (1384-1572): 1.22e-24: 112: 15.03
+	Hs
		907417 CUL3_HUMAN (1-768): 0: 943: 100.00		UBP11_HUMAN (1445-1581): 2.41e-22: 106: 21.99
+	Hs
		1113812 CUL3_HUMAN (1-768): 0: 943: 100.00		UBP33_HUMAN (855-1082): 2.83e-20: 100: 8.73
+	Hs
		1114742 CUL3_HUMAN (1-768): 0: 943: 100.00		UBP15_HUMAN (897-1072): 5.71e-11: 69.7: 6.77
+	Hs
		1114820 CUL4A_HUMAN (10-768): 0: 801: 38.32		UBP10_HUMAN (1010-1569): 3.8e-36: 150: 13.27
+	Hs
		1115193 CUL4B_HUMAN (5-768): 0: 796: 36.77		UBP10_HUMAN (1010-1569): 3.8e-36: 150: 13.27
+	Hs
		1094536 CUL4A_HUMAN (10-768): 0: 801: 38.32		UBP4_HUMAN (1430-1596): 1.67e-25: 117: 21.39
+	Hs
		322937 CUL4A_HUMAN (10-768): 0: 801: 38.32		UBP19_HUMAN (1339-1585): 3.61e-24: 113: 14.84
+	Hs
		1094537 CUL4B_HUMAN (5-768): 0: 796: 36.77		UBP4_HUMAN (1430-1596): 1.67e-25: 117: 21.39
+	Hs
		322938 CUL4B_HUMAN (5-768): 0: 796: 36.77		UBP19_HUMAN (1339-1585): 3.61e-24: 113: 14.84
+	Hs
		907418 CUL4B_HUMAN (5-768): 0: 796: 36.77		UBP11_HUMAN (1445-1581): 2.41e-22: 106: 21.99
+	Hs
		1115495 CUL4B_HUMAN (5-768): 0: 796: 36.77		UBP15_HUMAN (897-1072): 5.71e-11: 69.7: 6.77
+	Hs
		907416 CUL1_HUMAN (18-768): 0: 709: 30.57		UBP11_HUMAN (1445-1581): 2.41e-22: 106: 21.99
+	Sp
		237956 CUL3_SCHPO (11-768): 0: 648: 37.04		UBP12_SCHPO (1405-1568): 3.02e-18: 93.6: 22.42