HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: UB2E2 (Q96LR5)
Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2)
Gene: UBE2E2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19256485
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Cullin_Nedd8~UQ_con
Common GO terms	GO:0005634 - nucleus GO:0006513 - protein monoubiquitination GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 201
+	Hs
		1113924 CUL3_HUMAN (1-768): 0: 943: 100.00		UB2E3_HUMAN (1-201): 1.21e-83: 248: 81.64
+	Hs
		982183 CUL3_HUMAN (1-768): 0: 943: 100.00		UB2D2_HUMAN (55-200): 9.65e-82: 240: 64.38
+	Hs
		906661 CUL3_HUMAN (1-768): 0: 943: 100.00		UB2D1_HUMAN (55-200): 3.67e-81: 239: 61.64
+	Hs
		909316 CUL3_HUMAN (1-768): 0: 943: 100.00		UB2E1_HUMAN (28-201): 3.78e-79: 236: 90.29
+	Hs
		957733 CUL3_HUMAN (1-768): 0: 943: 100.00		UBE2N_HUMAN (53-200): 1.92e-69: 210: 45.27
+	Hs
		1114986 CUL4A_HUMAN (10-768): 0: 801: 38.32		UB2E3_HUMAN (1-201): 1.21e-83: 248: 81.64
+	Hs
		906662 CUL4A_HUMAN (10-768): 0: 801: 38.32		UB2D1_HUMAN (55-200): 3.67e-81: 239: 61.64
+	Hs
		957076 CUL4A_HUMAN (10-768): 0: 801: 38.32		UB2D3_HUMAN (55-200): 3.58e-80: 237: 63.70
+	Hs
		957077 CUL4B_HUMAN (5-768): 0: 796: 36.77		UB2D3_HUMAN (55-200): 3.58e-80: 237: 63.70
+	Hs
		884326 CUL4B_HUMAN (5-768): 0: 796: 36.77		UBE2A_HUMAN (54-198): 1.21e-69: 210: 35.86
+	Hs
		1112645 CUL1_HUMAN (18-768): 0: 709: 30.57		UB2E3_HUMAN (1-201): 1.21e-83: 248: 81.64
+	At
		1320288 CUL4_ARATH (8-768): 0: 748: 38.61		COP10_ARATH (43-200): 9.04e-62: 191: 55.98
+	Hs
		906660 CUL2_HUMAN (30-768): 0: 673: 26.17		UB2D1_HUMAN (55-200): 3.67e-81: 239: 61.64
+	Dm
		683045 CUL1_DROME (29-768): 0: 671: 27.49		UBCD1_DROME (55-200): 3.75e-81: 239: 64.38
+	Hs
		957075 CUL2_HUMAN (30-768): 0: 673: 26.17		UB2D3_HUMAN (55-200): 3.58e-80: 237: 63.70
+	Sp
		857678 CUL3_SCHPO (11-768): 0: 648: 37.04		UBC4_SCHPO (55-200): 3.01e-80: 237: 65.07