HitPredict

Interactor 1: UBCD1 (P25867)
Ubiquitin-conjugating enzyme E2-17 kDa (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D1) (Protein effete) (Ubiquitin carrier protein) (Ubiquitin-protein ligase)
Gene: eff

Interactor 2: CUL1 (Q24311)
Cullin homolog 1 (Lin-19 homolog protein)
Gene: CUL1

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.24	1.00	0.492

Property	Details
Experiments	unassigned4
Identification Methods	experimental interaction detection
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin_Nedd8~UQ_con
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0031625 - ubiquitin protein ligase binding GO:0045879 - negative regulation of smoothened signaling pathway
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 147 Dm			1 774
+	Hs
		1112645 UB2E3_HUMAN (4-146): 1.2e-73: 220: 65.73		CUL1_HUMAN (3-774): 0: 821: 61.68
+	Hs
		906662 UB2D1_HUMAN (1-147): 7.08e-83: 241: 89.12		CUL4A_HUMAN (17-774): 0: 767: 29.84
+	Hs
		906661 UB2D1_HUMAN (1-147): 7.08e-83: 241: 89.12		CUL3_HUMAN (3-774): 0: 764: 27.45
+	Hs
		957076 UB2D3_HUMAN (1-147): 1.96e-81: 238: 93.88		CUL4A_HUMAN (17-774): 0: 767: 29.84
+	Hs
		982183 UB2D2_HUMAN (1-147): 1.7e-82: 240: 94.56		CUL3_HUMAN (3-774): 0: 764: 27.45
+	Hs
		1114986 UB2E3_HUMAN (4-146): 1.2e-73: 220: 65.73		CUL4A_HUMAN (17-774): 0: 767: 29.84
+	Hs
		957077 UB2D3_HUMAN (1-147): 1.96e-81: 238: 93.88		CUL4B_HUMAN (3-774): 0: 749: 29.18
+	Hs
		1114027 UB2E2_HUMAN (4-146): 2.63e-74: 221: 65.73		CUL3_HUMAN (3-774): 0: 764: 27.45
+	Hs
		1113924 UB2E3_HUMAN (4-146): 1.2e-73: 220: 65.73		CUL3_HUMAN (3-774): 0: 764: 27.45
+	Hs
		909316 UB2E1_HUMAN (4-146): 3.43e-72: 216: 65.73		CUL3_HUMAN (3-774): 0: 764: 27.45
+	Hs
		906660 UB2D1_HUMAN (1-147): 7.08e-83: 241: 89.12		CUL2_HUMAN (7-774): 0: 729: 33.04
+	Hs
		957733 UBE2N_HUMAN (4-147): 4.8e-69: 206: 49.31		CUL3_HUMAN (3-774): 0: 764: 27.45
+	Hs
		957075 UB2D3_HUMAN (1-147): 1.96e-81: 238: 93.88		CUL2_HUMAN (7-774): 0: 729: 33.04
+	Hs
		884326 UBE2A_HUMAN (2-144): 1e-70: 211: 39.16		CUL4B_HUMAN (3-774): 0: 749: 29.18
+	At
		1320288 COP10_ARATH (4-146): 2.99e-58: 180: 58.04		CUL4_ARATH (17-774): 0: 713: 29.41
+	Sp
		857678 UBC4_SCHPO (1-147): 1.3e-80: 235: 87.08		CUL3_SCHPO (12-774): 0: 619: 25.71