HitPredict

Interactor 1: APR (Q13794)
Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa)
Gene: PMAIP1

Interactor 2: B2LA1 (Q16548)
Bcl-2-related protein A1 (Bcl-2-like protein 5) (Bcl2-L-5) (Hemopoietic-specific early response protein) (Protein BFL-1) (Protein GRS)
Gene: BCL2A1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.27	1.00	0.527

Property	Details
Experiments	15694340
Identification Methods	unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Bcl-2~PMAIP1
Common GO terms	GO:0001836 - release of cytochrome c from mitochondria GO:0005741 - mitochondrial outer membrane GO:0005829 - cytosol GO:0043065 - positive regulation of apoptotic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 54 Hs			1 175
+	Mm
		1059305 APR_MOUSE (1-50): 1.52e-19: 75.9: 66.67		B2LA1_MOUSE (1-172): 3.1e-64: 196: 72.09
+	Hs
		1060083 APR_HUMAN (1-54): 2.85e-26: 91.7: 100.00		BAX_HUMAN (11-173): 2.13e-47: 154: 23.93
+	Hs
		1060259 APR_HUMAN (1-54): 2.85e-26: 91.7: 100.00		MCL1_HUMAN (5-172): 3.36e-44: 151: 22.47
+	Hs
		522091 APR_HUMAN (1-54): 2.85e-26: 91.7: 100.00		BCL2_HUMAN (27-150): 1.77e-41: 141: 27.42
+	Hs
		1060165 APR_HUMAN (1-54): 2.85e-26: 91.7: 100.00		B2CL1_HUMAN (30-173): 1.93e-40: 137: 21.02
+	Mm
		1021080 APR_MOUSE (1-50): 1.52e-19: 75.9: 66.67		MCL1_MOUSE (5-172): 1.13e-43: 149: 22.78
+	Hs
		1117290 APR_HUMAN (1-54): 2.85e-26: 91.7: 100.00		B2CL2_HUMAN (22-149): 8.97e-36: 124: 19.53