Protein: APR
Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa)

Gene: APR, PMAIP1
Organism: Homo sapiens
Interactions: 181
UniProt ID: Q13794

Gene Ontology (top 5):
GO:0001836 - release of cytochrome c from mitochondria
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1060259

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

22

7

Small-scale

0.988

High

1060165

B2CL1
Bcl-2-like protein 1

4

7

Small-scale

0.885

High

522091

BCL2
Apoptosis regulator Bcl-2

3

7

Small-scale

0.861

High

1117290

B2CL2
Bcl-2-like protein 2

1

7

Small-scale

0.692

High

956285

RAB2A
Ras-related protein Rab-2A

3

3

High-throughput

0.653

High

1060083

BAX
Apoptosis regulator BAX

1

7

Small-scale

0.618

High

1117270

IRF3
Interferon regulatory factor 3

2

1

Small-scale

0.584

High

1117320

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

High-throughput

0.537

High

1117278

B2LA1
Bcl-2-related protein A1

1

7

Small-scale

0.527

High

1051369

ZBT16
Zinc finger and BTB domain-containing protein 16

1

0

High-throughput

0.518

High

1117310

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.513

High

906663

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

2

High-throughput

0.501

High

982184

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

2

High-throughput

0.501

High

1117317

RBX2
RING-box protein 2

1

1

Small-scale

0.501

High

891531

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.486

High

217438

E41L2
Band 4.1-like protein 2

1

2

High-throughput

0.479

High

321235

ERLN2
Erlin-2

1

1

High-throughput

0.479

High

375501

RASK
GTPase KRas

1

7

High-throughput

0.479

High

418662

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

3

High-throughput

0.479

High

452255

PDIA1
Protein disulfide-isomerase

1

1

High-throughput

0.479

High

475964

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

3

High-throughput

0.479

High

539804

RALA
Ras-related protein Ral-A

1

7

High-throughput

0.479

High

577747

PLAK
Junction plakoglobin

1

1

High-throughput

0.479

High

582782

EZRI
Ezrin

1

2

High-throughput

0.479

High

612219

ARF4
ADP-ribosylation factor 4

1

1

High-throughput

0.479

High

629850

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

631208

RAB5A
Ras-related protein Rab-5A

1

3

High-throughput

0.479

High

631646

RAB6A
Ras-related protein Rab-6A

1

4

High-throughput

0.479

High

661265

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

3

High-throughput

0.479

High

716290

PRDX6
Peroxiredoxin-6

1

1

High-throughput

0.479

High

901229

RAB7A
Ras-related protein Rab-7a

1

4

High-throughput

0.479

High

901803

RAB9A
Ras-related protein Rab-9A

1

4

High-throughput

0.479

High

955147

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.479

High

956718

RAB10
Ras-related protein Rab-10

1

2

High-throughput

0.479

High

957734

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

2

High-throughput

0.479

High

957922

RAB14
Ras-related protein Rab-14

1

3

High-throughput

0.479

High

962031

RHOA
Transforming protein RhoA

1

1

High-throughput

0.479

High

970469

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

976258

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.479

High

982076

RAP1A
Ras-related protein Rap-1A

1

5

High-throughput

0.479

High

983477

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

1

High-throughput

0.479

High

983796

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

High-throughput

0.479

High

984106

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.479

High

986850

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

1

1

High-throughput

0.479

High

989732

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

3

High-throughput

0.479

High

1026885

FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3

1

1

High-throughput

0.479

High

1031785

LAT1
Large neutral amino acids transporter small subunit 1

1

1

High-throughput

0.479

High

1087103

STX4
Syntaxin-4

1

2

High-throughput

0.479

High

1117273

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.479

High

1117276

VAMP3
Vesicle-associated membrane protein 3

1

1

High-throughput

0.479

High

1117289

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

1

High-throughput

0.479

High

1117291

IRF7
Interferon regulatory factor 7

1

1

Small-scale

0.479

High

1117294

UBE2F
NEDD8-conjugating enzyme UBE2F

1

2

Small-scale

0.479

High

1117303

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

1

1

High-throughput

0.479

High

1117305

RAB1B
Ras-related protein Rab-1B

1

1

High-throughput

0.479

High

1117312

ARL8B
ADP-ribosylation factor-like protein 8B

1

3

High-throughput

0.479

High

1117319

STML2
Stomatin-like protein 2, mitochondrial

1

1

High-throughput

0.479

High

1117322

E41L3
Band 4.1-like protein 3

1

2

High-throughput

0.479

High

1117323

RAP2C
Ras-related protein Rap-2c

1

5

High-throughput

0.479

High

124051

SNP23
Synaptosomal-associated protein 23

1

0

High-throughput

0.458

High

125739

STXB3
Syntaxin-binding protein 3

1

0

High-throughput

0.458

High

130093

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.458

High

137439

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

1

0

High-throughput

0.458

High

219628

B2L11
Bcl-2-like protein 11

1

0

Small-scale

0.458

High

228252

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.458

High

255423

SNX2
Sorting nexin-2

1

0

High-throughput

0.458

High

258123

IF2P
Eukaryotic translation initiation factor 5B

1

0

High-throughput

0.458

High

271253

CPNE3
Copine-3

1

0

High-throughput

0.458

High

276834

VATG1
V-type proton ATPase subunit G 1

1

0

High-throughput

0.458

High

291648

XRP2
Protein XRP2

1

0

High-throughput

0.458

High

298380

DNJC8
DnaJ homolog subfamily C member 8

1

0

High-throughput

0.458

High

360413

COX2
Cytochrome c oxidase subunit 2

1

0

High-throughput

0.458

High

424405

HMGN1
Non-histone chromosomal protein HMG-14

1

0

High-throughput

0.458

High

456722

ANXA2
Annexin A2

1

0

High-throughput

0.458

High

488472

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

0

Small-scale

0.458

High

548496

MPRI
Cation-independent mannose-6-phosphate receptor

1

0

High-throughput

0.458

High

553815

KCRU
Creatine kinase U-type, mitochondrial

1

0

High-throughput

0.458

High

559949

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

568412

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

572359

CX7A2
Cytochrome c oxidase subunit 7A2, mitochondrial

1

0

High-throughput

0.458

High

590370

COX7C
Cytochrome c oxidase subunit 7C, mitochondrial

1

0

High-throughput

0.458

High

593104

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

Small-scale

0.458

High

634106

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.458

High

697107

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

717303

PEBP1
Phosphatidylethanolamine-binding protein 1

1

0

High-throughput

0.458

High

766533

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

773494

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.458

High

774342

BASI
Basigin

1

0

High-throughput

0.458

High

791010

TALDO
Transaldolase

1

0

High-throughput

0.458

High

828649

MDHC
Malate dehydrogenase, cytoplasmic

1

0

High-throughput

0.458

High

894543

GDIB
Rab GDP dissociation inhibitor beta

1

0

High-throughput

0.458

High

903903

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

906051

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.458

High

910891

IMA1
Importin subunit alpha-1

1

0

High-throughput

0.458

High

929783

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

932465

KAD2
Adenylate kinase 2, mitochondrial

1

0

High-throughput

0.458

High

934072

XPO2
Exportin-2

1

0

High-throughput

0.458

High

946405

MTPN
Myotrophin

1

0

High-throughput

0.458

High

958943

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

968911

PRS8
26S proteasome regulatory subunit 8

1

0

High-throughput

0.458

High

1058409

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.458

High

1096954

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.458

High

1107699

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

1117268

COX17
Cytochrome c oxidase copper chaperone

1

0

High-throughput

0.458

High

1117272

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.458

High

1117277

NEDD8
Ubiquitin-like protein NEDD8

1

0

High-throughput

0.458

High

1117279

TB10B
TBC1 domain family member 10B

1

0

High-throughput

0.458

High

1117280

COA6
Cytochrome c oxidase assembly factor 6 homolog

1

0

High-throughput

0.458

High

1117282

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

Small-scale

0.458

High

1117288

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.458

High

1117292

CUL5
Cullin-5

1

0

Small-scale

0.458

High

1117293

STMN2
Stathmin-2

1

0

High-throughput

0.458

High

1117296

CC124
Coiled-coil domain-containing protein 124

1

0

High-throughput

0.458

High

1117297

ERO1A
ERO1-like protein alpha

1

0

High-throughput

0.458

High

1117299

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.458

High

1117300

DNJC7
DnaJ homolog subfamily C member 7

1

0

High-throughput

0.458

High

1117301

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

1117307

GCP60
Golgi resident protein GCP60

1

0

High-throughput

0.458

High

1117308

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.458

High

1117309

SFXN1
Sideroflexin-1

1

0

High-throughput

0.458

High

1117313

NDUBB
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

1

0

High-throughput

0.458

High

1117314

HYPK
Huntingtin-interacting protein K

1

0

High-throughput

0.458

High

1117316

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.458

High

1117321

HIG1A
HIG1 domain family member 1A, mitochondrial

1

0

High-throughput

0.458

High

1117324

TBL2
Transducin beta-like protein 2

1

0

High-throughput

0.458

High

189558

STX7
Syntaxin-7

1

2

High-throughput

0.437

High

280199

SC22B
Vesicle-trafficking protein SEC22b

1

1

High-throughput

0.437

High

349317

GNA14
Guanine nucleotide-binding protein subunit alpha-14

1

2

High-throughput

0.437

High

420527

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.437

High

420792

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

1

High-throughput

0.437

High

598080

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

2

High-throughput

0.437

High

627330

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

3

High-throughput

0.437

High

722456

CTR1
High affinity cationic amino acid transporter 1

1

2

High-throughput

0.437

High

844771

EAA1
Excitatory amino acid transporter 1

1

1

High-throughput

0.437

High

863467

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

1

High-throughput

0.437

High

888860

TMEDA
Transmembrane emp24 domain-containing protein 10

1

2

High-throughput

0.437

High

900805

RAB5C
Ras-related protein Rab-5C

1

4

High-throughput

0.437

High

908009

VAMP7
Vesicle-associated membrane protein 7

1

1

High-throughput

0.437

High

931357

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

1

High-throughput

0.437

High

967204

RRAS2
Ras-related protein R-Ras2

1

6

High-throughput

0.437

High

1117271

PDIA6
Protein disulfide-isomerase A6

1

2

High-throughput

0.437

High

1117274

TMED2
Transmembrane emp24 domain-containing protein 2

1

2

High-throughput

0.437

High

1117275

AAAT
Neutral amino acid transporter B(0)

1

1

High-throughput

0.437

High

1117283

STX12
Syntaxin-12

1

2

High-throughput

0.437

High

1117284

AT11C
Phospholipid-transporting ATPase IG

1

1

High-throughput

0.437

High

1117285

TXND5
Thioredoxin domain-containing protein 5

1

2

High-throughput

0.437

High

1117287

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

1

High-throughput

0.437

High

1117298

BT3L4
Transcription factor BTF3 homolog 4

1

1

High-throughput

0.437

High

1117304

TMED9
Transmembrane emp24 domain-containing protein 9

1

2

High-throughput

0.437

High

1117306

TMX1
Thioredoxin-related transmembrane protein 1

1

3

High-throughput

0.437

High

1117325

SRPRB
Signal recognition particle receptor subunit beta

1

2

High-throughput

0.437

High

62118

KLRG2
Killer cell lectin-like receptor subfamily G member 2

1

0

High-throughput

0.249

Low

138379

ZN593
Zinc finger protein 593

1

0

High-throughput

0.249

Low

165579

SCAM3
Secretory carrier-associated membrane protein 3

1

0

High-throughput

0.249

Low

215424

TPD54
Tumor protein D54

1

0

High-throughput

0.249

Low

293669

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

295820

FACE1
CAAX prenyl protease 1 homolog

1

0

High-throughput

0.249

Low

329746

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

1

0

High-throughput

0.249

Low

390564

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.249

Low

409376

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

0

High-throughput

0.249

Low

418116

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

467479

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.249

Low

483571

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.249

Low

571144

CD99
CD99 antigen

1

0

High-throughput

0.249

Low

571430

GLU2B
Glucosidase 2 subunit beta

1

0

High-throughput

0.249

Low

716474

DOPD
D-dopachrome decarboxylase

1

0

High-throughput

0.249

Low

813083

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.249

Low

877434

PIPNB
Phosphatidylinositol transfer protein beta isoform

1

0

High-throughput

0.249

Low

880543

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.249

Low

925531

MOT1
Monocarboxylate transporter 1

1

0

High-throughput

0.249

Low

933399

S12A2
Solute carrier family 12 member 2

1

0

High-throughput

0.249

Low

1010617

DCD
Dermcidin

1

0

High-throughput

0.249

Low

1117269

DSG2
Desmoglein-2

1

0

High-throughput

0.249

Low

1117281

ATRAP
Type-1 angiotensin II receptor-associated protein

1

0

High-throughput

0.249

Low

1117286

KLDC4
Kelch domain-containing protein 4

1

0

High-throughput

0.249

Low

1117295

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.249

Low

1117302

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.249

Low

1117311

CC50A
Cell cycle control protein 50A

1

0

High-throughput

0.249

Low

1117315

HACD3
Very-long-chain

1

0

High-throughput

0.249

Low

1117318

GBG12

1

0

High-throughput

0.249

Low

390331

CXCL7
Platelet basic protein

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025