HitPredict

Interactor 1: SCRIB (Q14160)
Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)
Gene: SCRIB

Interactor 2: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	38280479, 34439242, 30126976, 22078877
Identification Methods	proximity labelling technology, affinity chromatography technology, p8 filamentous phage display, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1655 Hs			1 400
+	Hs
		862125 SCRIB_HUMAN (1-1655): 0: 940: 100.00		YAP1_HUMAN (14-400): 3.69e-97: 300: 41.13
+	Hs
		1429033 MFHA1_HUMAN (79-386): 6.84e-31: 134: 35.37		WWTR1_HUMAN (1-400): 5.18e-126: 371: 100.00
+	Hs
		299786 MPDZ_HUMAN (785-1091): 2.82e-25: 117: 21.98		WWTR1_HUMAN (1-400): 5.18e-126: 371: 100.00
+	Hs
		1091567 DLG1_HUMAN (687-910): 5.8e-15: 82.9: 24.68		WWTR1_HUMAN (1-400): 5.18e-126: 371: 100.00
+	Hs
		1401928 ERBIN_HUMAN (541-949): 3.85e-10: 67.1: 13.27		WWTR1_HUMAN (1-400): 5.18e-126: 371: 100.00
+	Hs
		299749 MPDZ_HUMAN (785-1091): 2.82e-25: 117: 21.98		YAP1_HUMAN (14-400): 3.69e-97: 300: 41.13
+	Hs
		862089 DLG1_HUMAN (687-910): 5.8e-15: 82.9: 24.68		YAP1_HUMAN (14-400): 3.69e-97: 300: 41.13
+	Hs
		862395 ERBIN_HUMAN (541-949): 3.85e-10: 67.1: 13.27		YAP1_HUMAN (14-400): 3.69e-97: 300: 41.13
+	Mm
		1223740 DLG4_MOUSE (812-1187): 1.23e-48: 188: 22.42		MAGI3_MOUSE (3-246): 7.57e-44: 165: 18.88
+	Mm
		1223651 DLG4_MOUSE (812-1187): 1.23e-48: 188: 22.42		NED4L_MOUSE (129-395): 4.78e-24: 106: 11.96
+	Hs
		1260704 DLG3_HUMAN (724-947): 1.79e-19: 97.4: 31.23		HECW1_HUMAN (14-327): 1.33e-53: 193: 14.29
+	Mm
		97740 DLG4_MOUSE (812-1187): 1.23e-48: 188: 22.42		E9PXB7_MOUSE (129-395): 7.94e-23: 102: 12.68
+	Hs
		1401929 ERBIN_HUMAN (541-949): 3.85e-10: 67.1: 13.27		WWP1_HUMAN (3-386): 5.13e-64: 222: 13.86
+	Hs
		299769 MPDZ_HUMAN (785-1091): 2.82e-25: 117: 21.98		KIBRA_HUMAN (123-265): 3.1e-45: 169: 18.88
+	Hs
		1091535 DLG1_HUMAN (687-910): 5.8e-15: 82.9: 24.68		KIBRA_HUMAN (123-265): 3.1e-45: 169: 18.88
+	Hs
		299803 MPDZ_HUMAN (785-1091): 2.82e-25: 117: 21.98		WWOX_HUMAN (111-236): 1.79e-18: 88.4: 21.09
+	Mm
		97734 DLG3_MOUSE (724-947): 3.66e-19: 96.3: 31.23		E9PXB7_MOUSE (129-395): 7.94e-23: 102: 12.68
+	Mm
		861864 DLG3_MOUSE (724-947): 3.66e-19: 96.3: 31.23		NEDD4_MOUSE (129-328): 8.7e-21: 96.6: 10.44
+	Hs
		1368713 DLG3_HUMAN (724-947): 1.79e-19: 97.4: 31.23		NED4L_HUMAN (164-352): 3.04e-13: 73.5: 13.20