HitPredict

Interactor 1: DPYL3 (Q14195)
Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1)
Gene: DPYSL3

Interactor 2: DPYL5 (Q9BPU6)
Dihydropyrimidinase-related protein 5 (DRP-5) (CRMP3-associated molecule) (CRAM) (Collapsin response mediator protein 5) (CRMP-5) (UNC33-like phosphoprotein 6) (ULIP-6)
Gene: DPYSL5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.902

Property	Details
Experiments	32296183, 28514442, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Amidohydro_1~Amidohydro_1
Common GO terms	GO:0005829 - cytosol GO:0016812 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 570 Hs			1 564
+	Hs
		1123192 DPYL3_HUMAN (1-570): 0: 765: 100.00		DPYL1_HUMAN (6-561): 0: 729: 50.81
+	Hs
		1123248 DPYL3_HUMAN (1-570): 0: 765: 100.00		DPYL2_HUMAN (6-561): 0: 726: 51.71
+	Hs
		1158677 Q8IXW6_HUMAN (1-570): 0: 765: 99.83		DPYL2_HUMAN (6-561): 0: 726: 51.71
+	Mm
		1021377 DPYL3_MOUSE (1-570): 0: 764: 98.42		DPYL1_MOUSE (6-561): 0: 723: 50.27
+	Mm
		1223877 DPYL3_MOUSE (1-570): 0: 764: 98.42		DPYL5_MOUSE (1-564): 0: 723: 97.87
+	Hs
		155851 DPYL3_HUMAN (1-570): 0: 765: 100.00		DPYL4_HUMAN (6-561): 0: 715: 49.46
+	Hs
		1123191 DPYL1_HUMAN (1-569): 0: 748: 74.43		DPYL1_HUMAN (6-561): 0: 729: 50.81
+	Hs
		1123198 DPYL1_HUMAN (1-569): 0: 748: 74.43		DPYL2_HUMAN (6-561): 0: 726: 51.71
+	Hs
		1158698 DPYL2_HUMAN (1-569): 0: 742: 76.71		DPYL5_HUMAN (1-564): 0: 727: 100.00
+	Hs
		1158660 DPYL2_HUMAN (1-569): 0: 742: 76.71		DPYL2_HUMAN (6-561): 0: 726: 51.71
+	Hs
		1158727 DPYL2_HUMAN (1-569): 0: 742: 76.71		X5DQV1_HUMAN (4-561): 0: 725: 50.81
+	Rn
		868848 DPYL2_RAT (1-569): 0: 740: 77.41		DPYL2_RAT (6-561): 0: 725: 52.24
+	Hs
		155850 DPYL1_HUMAN (1-569): 0: 748: 74.43		DPYL4_HUMAN (6-561): 0: 715: 49.46
+	Hs
		155854 DPYL2_HUMAN (1-569): 0: 742: 76.71		DPYL4_HUMAN (6-561): 0: 715: 49.46
+	Hs
		1120598 DPYL3_HUMAN (1-570): 0: 765: 100.00		DPYS_HUMAN (5-518): 0: 665: 57.53
+	Hs
		1120600 DPYL2_HUMAN (1-569): 0: 742: 76.71		DPYS_HUMAN (5-518): 0: 665: 57.53