HitPredict

Interactor 1: SH21B (O14796)
SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)
Gene: SH2D1B

Interactor 2: PTN18 (Q99952)
Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase)
Gene: PTPN18

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	23322602
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 132 Hs			1 460
+	Hs
		782792 CSK_HUMAN (3-131): 2.76e-35: 127: 23.26		PTPRO_HUMAN (4-309): 5.69e-133: 414: 30.23
+	Hs
		616905 CSK_HUMAN (3-131): 2.76e-35: 127: 23.26		PTPRB_HUMAN (5-315): 1.47e-127: 409: 31.66
+	Hs
		782777 CSK_HUMAN (3-131): 2.76e-35: 127: 23.26		PTN12_HUMAN (4-413): 2.43e-135: 409: 35.73
+	Hs
		412016 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		PTPRD_HUMAN (4-294): 1.55e-107: 351: 32.44
+	Rn
		1144045 FYN_RAT (3-125): 5.38e-35: 128: 22.48		Q66HJ7_RAT (8-307): 1.68e-109: 343: 32.57
+	Hs
		411997 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		PTPRA_HUMAN (4-307): 3.85e-109: 342: 32.79
+	Hs
		411959 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		PTPRF_HUMAN (3-294): 1.09e-103: 341: 31.33
+	Mm
		56907 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		PTPRF_MOUSE (31-294): 1.38e-103: 340: 33.58
+	Hs
		412017 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		PTPRE_HUMAN (5-307): 4.4e-101: 318: 30.77
+	Hs
		411950 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		PTPRC_HUMAN (4-362): 2.82e-80: 272: 24.31
+	Hs
		441186 CSK_HUMAN (3-131): 2.76e-35: 127: 23.26		PTPRC_HUMAN (4-362): 2.82e-80: 272: 24.31
+	Rn
		94284 FYN_RAT (3-125): 5.38e-35: 128: 22.48		F1LXJ9_RAT (22-294): 1.35e-62: 222: 27.76
+	Hs
		782790 CSK_HUMAN (3-131): 2.76e-35: 127: 23.26		PTPRK_HUMAN (9-295): 9.98e-62: 219: 26.10
+	Hs
		617084 CSK_HUMAN (3-131): 2.76e-35: 127: 23.26		PTPRG_HUMAN (4-316): 2.2e-57: 206: 24.77
+	Hs
		412018 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		PTPRZ_HUMAN (25-315): 2.81e-56: 203: 26.82
+	Hs
		617158 CSK_HUMAN (3-131): 2.76e-35: 127: 23.26		PTPRZ_HUMAN (25-315): 2.81e-56: 203: 26.82
+	Hs
		412035 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		PTN4_HUMAN (54-292): 1.28e-48: 180: 39.59
+	Hs
		782783 CSK_HUMAN (3-131): 2.76e-35: 127: 23.26		PTPRJ_HUMAN (50-313): 1.3e-44: 169: 38.04
+	Hs
		412146 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		PTN11_HUMAN (51-297): 6.26e-45: 167: 38.70
+	Mm
		574000 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		PTPRA_MOUSE (13-292): 3.81e-32: 132: 26.56