HitPredict

Interactor 1: DSC3 (Q14574)
Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP)
Gene: DSC3

Interactor 2: PKP4 (Q99569)
Plakophilin-4 (p0071)
Gene: PKP4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	12615965
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Arm~CADH_Y-type_LIR
Common GO terms	GO:0001533 - cornified envelope GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0030054 - cell junction and 2 others more... GO:0030057 - desmosome GO:0098609 - cell-cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 896 Hs			1 1192
+	Hs
		1128566 DSC3_HUMAN (1-896): 0: 973: 100.00		PKP3_HUMAN (218-1014): 3.22e-152: 478: 26.92
+	Hs
		764751 DSC3_HUMAN (1-896): 0: 973: 100.00		CTNB1_HUMAN (311-1123): 7.92e-149: 468: 16.00
+	Hs
		1037033 DSC2_HUMAN (1-896): 0: 905: 66.59		PKP2_HUMAN (156-1014): 3.13e-160: 501: 24.78
+	Hs
		1037059 DSC2_HUMAN (1-896): 0: 905: 66.59		PKP3_HUMAN (218-1014): 3.22e-152: 478: 26.92
+	Hs
		577757 DSC3_HUMAN (1-896): 0: 973: 100.00		PLAK_HUMAN (316-1101): 5.06e-125: 404: 16.54
+	Hs
		1064473 DSC1_HUMAN (31-896): 0: 808: 51.83		PKP2_HUMAN (156-1014): 3.13e-160: 501: 24.78
+	Hs
		577720 DSC2_HUMAN (1-896): 0: 905: 66.59		PLAK_HUMAN (316-1101): 5.06e-125: 404: 16.54
+	Hs
		1064490 DSC1_HUMAN (31-896): 0: 808: 51.83		PKP3_HUMAN (218-1014): 3.22e-152: 478: 26.92
+	Hs
		577728 DSC1_HUMAN (31-896): 0: 808: 51.83		PLAK_HUMAN (316-1101): 5.06e-125: 404: 16.54
+	Hs
		1064424 DSC1_HUMAN (31-896): 0: 808: 51.83		PKP1_HUMAN (413-1009): 4.24e-124: 401: 28.59
+	Hs
		748668 DSG3_HUMAN (108-892): 0: 590: 27.56		PKP3_HUMAN (218-1014): 3.22e-152: 478: 26.92
+	Hs
		646699 CADH3_HUMAN (10-891): 0: 577: 27.49		CTNB1_HUMAN (311-1123): 7.92e-149: 468: 16.00
+	Hs
		577640 DSG3_HUMAN (108-892): 0: 590: 27.56		PLAK_HUMAN (316-1101): 5.06e-125: 404: 16.54
+	Hs
		577616 CADH3_HUMAN (10-891): 0: 577: 27.49		PLAK_HUMAN (316-1101): 5.06e-125: 404: 16.54
+	Hs
		254054 CADH3_HUMAN (10-891): 0: 577: 27.49		CTND1_HUMAN (26-872): 2.73e-72: 263: 14.02
+	Hs
		1036791 DSG1_HUMAN (130-573): 7.18e-68: 247: 32.29		PKP2_HUMAN (156-1014): 3.13e-160: 501: 24.78
+	Hs
		1036823 DSG1_HUMAN (130-573): 7.18e-68: 247: 32.29		PKP3_HUMAN (218-1014): 3.22e-152: 478: 26.92
+	Hs
		765110 CADH7_HUMAN (5-347): 4.3e-49: 188: 19.56		CTNB1_HUMAN (311-1123): 7.92e-149: 468: 16.00
+	Hs
		577719 DSG1_HUMAN (130-573): 7.18e-68: 247: 32.29		PLAK_HUMAN (316-1101): 5.06e-125: 404: 16.54
+	Hs
		1036722 DSG1_HUMAN (130-573): 7.18e-68: 247: 32.29		PKP1_HUMAN (413-1009): 4.24e-124: 401: 28.59