Protein: DSG1
Desmoglein-1 (Cadherin family member 4) (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen)

Gene: DSG1
Organism: Homo sapiens
Interactions: 206
UniProt ID: Q02413

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0005509 - calcium ion binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

577719

PLAK
Junction plakoglobin

3

20

Small-scale

0.840

High

1036712

DSC1
Desmocollin-1

3

18

Small-scale

0.840

High

1036722

PKP1
Plakophilin-1

3

20

Small-scale

0.840

High

1036791

PKP2
Plakophilin-2

1

20

Small-scale

0.713

High

1036823

PKP3
Plakophilin-3

1

20

Small-scale

0.713

High

400682

RAF1
RAF proto-oncogene serine/threonine-protein kinase

4

7

High-throughput

0.672

High

371804

MYC
Myc proto-oncogene protein

3

9

High-throughput

0.640

High

1036706

DSC2
Desmocollin-2

1

17

Small-scale

0.618

High

1036813

PD1L1
Programmed cell death 1 ligand 1

1

10

High-throughput

0.618

High

395946

ESR1
Estrogen receptor

2

10

High-throughput

0.611

High

943838

CF298
Cilia- and flagella-associated protein 298

2

0

High-throughput

0.602

High

587628

DESP
Desmoplakin

2

11

Small-scale

0.595

High

413658

P53
Cellular tumor antigen p53

2

3

Small-scale

0.584

High

830590

CCNF
Cyclin-F

2

6

High-throughput

0.584

High

1036735

LARP7
La-related protein 7

2

2

High-throughput

0.584

High

1036819

FBW1A
F-box/WD repeat-containing protein 1A

2

1

High-throughput

0.584

High

1036807

TB22B
TBC1 domain family member 22B

2

6

High-throughput

0.574

High

463463

LYN
Tyrosine-protein kinase Lyn

2

11

High-throughput

0.571

High

521317

ARAF
Serine/threonine-protein kinase A-Raf

2

7

High-throughput

0.571

High

563644

CFTR
Cystic fibrosis transmembrane conductance regulator

2

6

Small-scale

0.571

High

593968

NCK1
SH2/SH3 adapter protein NCK1

2

12

High-throughput

0.571

High

717288

PEBP1
Phosphatidylethanolamine-binding protein 1

2

1

High-throughput

0.571

High

728181

AKT1
RAC-alpha serine/threonine-protein kinase

2

4

High-throughput

0.571

High

783560

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

2

9

High-throughput

0.571

High

902825

BLK
Tyrosine-protein kinase Blk

2

10

High-throughput

0.571

High

1036719

GAB1
GRB2-associated-binding protein 1

2

9

High-throughput

0.571

High

1036732

RBP1
RalA-binding protein 1

2

11

High-throughput

0.571

High

1036773

ARH40
Rho guanine nucleotide exchange factor 40

2

5

High-throughput

0.571

High

1036816

GAB2
GRB2-associated-binding protein 2

2

9

High-throughput

0.571

High

1036817

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

2

1

High-throughput

0.571

High

1036750

PRP8
Pre-mRNA-processing-splicing factor 8

2

0

High-throughput

0.559

High

584747

NDKA
Nucleoside diphosphate kinase A

2

0

High-throughput

0.547

High

317164

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

3

High-throughput

0.536

High

431098

LA
Lupus La protein

1

2

High-throughput

0.536

High

549122

CDK4
Cyclin-dependent kinase 4

1

5

High-throughput

0.536

High

584519

VAV
Proto-oncogene vav

1

5

High-throughput

0.536

High

602775

AATC
Aspartate aminotransferase, cytoplasmic

1

3

High-throughput

0.536

High

862809

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

6

High-throughput

0.536

High

919897

PLK1
Serine/threonine-protein kinase PLK1

1

3

High-throughput

0.536

High

943038

STX17
Syntaxin-17

1

2

High-throughput

0.536

High

1032285

OTUD4
OTU domain-containing protein 4

1

2

High-throughput

0.536

High

1036709

RAD51
DNA repair protein RAD51 homolog 1

1

1

High-throughput

0.536

High

1036716

MK07
Mitogen-activated protein kinase 7

1

6

High-throughput

0.536

High

1036721

CUL2
Cullin-2

1

6

High-throughput

0.536

High

1036729

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

1

High-throughput

0.536

High

1036731

PMVK
Phosphomevalonate kinase

1

1

High-throughput

0.536

High

1036752

SAMD1
Sterile alpha motif domain-containing protein 1

1

3

High-throughput

0.536

High

1036757

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

3

High-throughput

0.536

High

1036761

ZC3C1
Zinc finger C3HC-type protein 1

1

2

High-throughput

0.536

High

1036801

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

3

High-throughput

0.536

High

1036754

SYDE1
Rho GTPase-activating protein SYDE1

2

9

High-throughput

0.521

High

1036734

H2B2E
Histone H2B type 2-E

1

3

High-throughput

0.515

High

1036779

H2B1H
Histone H2B type 1-H

1

3

High-throughput

0.515

High

983644

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.513

High

1036778

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

955073

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.501

High

239040

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.493

High

773864

SOAT1
Sterol O-acyltransferase 1

1

1

High-throughput

0.489

High

1036775

ZDH19
Palmitoyltransferase ZDHHC19

1

6

High-throughput

0.489

High

141430

DDX3X
ATP-dependent RNA helicase DDX3X

1

2

Small-scale

0.479

High

180790

TIF1A
Transcription intermediary factor 1-alpha

1

11

Small-scale

0.479

High

241442

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

293585

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

302492

RNF8
E3 ubiquitin-protein ligase RNF8

1

5

High-throughput

0.479

High

323329

TRI37
E3 ubiquitin-protein ligase TRIM37

1

9

High-throughput

0.479

High

349042

LATS1
Serine/threonine-protein kinase LATS1

1

6

High-throughput

0.479

High

406081

MYCN
N-myc proto-oncogene protein

1

8

High-throughput

0.479

High

411764

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

423636

ARGI1
Arginase-1

1

1

High-throughput

0.479

High

456695

ANXA2
Annexin A2

1

7

High-throughput

0.479

High

487208

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

488458

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

3

Small-scale

0.479

High

537003

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

588501

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

606652

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

623288

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

635582

FILA
Filaggrin

1

5

High-throughput

0.479

High

655796

TBG1
Tubulin gamma-1 chain

1

5

High-throughput

0.479

High

667791

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.479

High

695251

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

729540

CASPE
Caspase-14

1

3

High-throughput

0.479

High

755884

MCM5
DNA replication licensing factor MCM5

1

4

High-throughput

0.479

High

848241

MAGA3
Melanoma-associated antigen 3

1

3

Small-scale

0.479

High

887986

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

908817

NEK2
Serine/threonine-protein kinase Nek2

1

6

Small-scale

0.479

High

926648

HIRA
Protein HIRA

1

3

Small-scale

0.479

High

951623

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

Small-scale

0.479

High

964584

DCAF7
DDB1- and CUL4-associated factor 7

1

5

High-throughput

0.479

High

970359

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

991014

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

2

High-throughput

0.479

High

1004461

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

1026321

HSF1
Heat shock factor protein 1

1

2

High-throughput

0.479

High

1030439

FABP5
Fatty acid-binding protein 5

1

1

High-throughput

0.479

High

1035545

KIF23
Kinesin-like protein KIF23

1

6

High-throughput

0.479

High

1036707

UBXN1
UBX domain-containing protein 1

1

3

High-throughput

0.479

High

1036708

K1C17
Keratin, type I cytoskeletal 17

1

2

High-throughput

0.479

High

1036710

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

2

High-throughput

0.479

High

1036713

RBBP4
Histone-binding protein RBBP4

1

3

High-throughput

0.479

High

1036714

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

2

High-throughput

0.479

High

1036717

ERCC8
DNA excision repair protein ERCC-8

1

7

High-throughput

0.479

High

1036720

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

1036723

DX39B
Spliceosome RNA helicase DDX39B

1

7

High-throughput

0.479

High

1036724

BLMH
Bleomycin hydrolase

1

2

High-throughput

0.479

High

1036725

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

5

High-throughput

0.479

High

1036726

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

2

High-throughput

0.479

High

1036727

TNIP1
TNFAIP3-interacting protein 1

1

10

High-throughput

0.479

High

1036728

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1036730

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.479

High

1036733

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

1036737

DCAF6
DDB1- and CUL4-associated factor 6

1

4

High-throughput

0.479

High

1036739

FILA2
Filaggrin-2

1

6

High-throughput

0.479

High

1036742

DCA12
DDB1- and CUL4-associated factor 12

1

1

High-throughput

0.479

High

1036743

KPRP
Keratinocyte proline-rich protein

1

1

High-throughput

0.479

High

1036746

SYDE2
Rho GTPase-activating protein SYDE2

1

11

High-throughput

0.479

High

1036747

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.479

High

1036753

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

1036756

DET1
DET1 homolog

1

1

High-throughput

0.479

High

1036758

ZN598
E3 ubiquitin-protein ligase ZNF598

1

3

High-throughput

0.479

High

1036759

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1036762

GOLI
E3 ubiquitin-protein ligase RNF130

1

6

High-throughput

0.479

High

1036763

HORN
Hornerin

1

5

High-throughput

0.479

High

1036764

VRK3
Serine/threonine-protein kinase VRK3

1

3

High-throughput

0.479

High

1036768

DOCK8
Dedicator of cytokinesis protein 8

1

1

High-throughput

0.479

High

1036769

NUP43
Nucleoporin Nup43

1

6

High-throughput

0.479

High

1036770

COP1
E3 ubiquitin-protein ligase COP1

1

6

High-throughput

0.479

High

1036771

CEP76
Centrosomal protein of 76 kDa

1

1

High-throughput

0.479

High

1036772

POC1B
POC1 centriolar protein homolog B

1

2

High-throughput

0.479

High

1036776

TOPB1
DNA topoisomerase 2-binding protein 1

1

5

High-throughput

0.479

High

1036777

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

1036780

KISSR
KiSS-1 receptor

1

3

Small-scale

0.479

High

1036781

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

2

Small-scale

0.479

High

1036782

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

6

High-throughput

0.479

High

1036785

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1036786

SPB12
Serpin B12

1

1

High-throughput

0.479

High

1036787

PKH4B
Pleckstrin homology domain-containing family G member 4B

1

4

High-throughput

0.479

High

1036788

RANB9
Ran-binding protein 9

1

6

Small-scale

0.479

High

1036793

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

11

High-throughput

0.479

High

1036794

FACD2
Fanconi anemia group D2 protein

1

3

High-throughput

0.479

High

1036795

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.479

High

1036797

DDX24
ATP-dependent RNA helicase DDX24

1

5

High-throughput

0.479

High

1036798

PRD14
PR domain zinc finger protein 14

1

2

Small-scale

0.479

High

1036800

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

1036802

S10AE
Protein S100-A14

1

7

High-throughput

0.479

High

1036803

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

1036805

ANLN
Anillin

1

5

High-throughput

0.479

High

1036806

FBX6
F-box only protein 6

1

3

High-throughput

0.479

High

1036808

DCA13
DDB1- and CUL4-associated factor 13

1

4

High-throughput

0.479

High

1036809

RNF12
E3 ubiquitin-protein ligase RLIM

1

8

High-throughput

0.479

High

1036810

CNTLN
Centlein

1

8

High-throughput

0.479

High

1036811

WSB2
WD repeat and SOCS box-containing protein 2

1

3

High-throughput

0.479

High

1036815

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1036818

RUVB1
RuvB-like 1

1

1

High-throughput

0.479

High

1036820

ST38L
Serine/threonine-protein kinase 38-like

1

5

High-throughput

0.479

High

1036821

FND3A
Fibronectin type-III domain-containing protein 3A

1

14

High-throughput

0.479

High

1036822

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

5

Small-scale

0.479

High

194147

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

345688

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

370292

CYTA
Cystatin-A

1

0

High-throughput

0.458

High

485080

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

926953

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

1036715

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

1036745

ARM12
Armadillo repeat-containing protein 12

1

0

Small-scale

0.458

High

1036748

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

0

High-throughput

0.458

High

1036749

CDC73
Parafibromin

1

0

High-throughput

0.458

High

1036751

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1036790

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1036814

MBD5
Methyl-CpG-binding domain protein 5

1

0

High-throughput

0.458

High

529661

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

641939

CD9
CD9 antigen

1

4

High-throughput

0.445

High

839451

PI4KA
Phosphatidylinositol 4-kinase alpha

1

7

High-throughput

0.445

High

934485

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.445

High

948794

CD81
CD81 antigen

1

4

Small-scale

0.445

High

952116

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

4

High-throughput

0.445

High

1023755

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

2

High-throughput

0.445

High

1034431

TAGL
Transgelin

1

8

High-throughput

0.445

High

1036738

ODFP2
Outer dense fiber protein 2

1

7

High-throughput

0.445

High

1036741

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

1036765

SULF2
Extracellular sulfatase Sulf-2

1

1

High-throughput

0.445

High

1036789

ZBT18
Zinc finger and BTB domain-containing protein 18

1

4

High-throughput

0.445

High

1036796

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

4

High-throughput

0.445

High

1036799

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

4

High-throughput

0.445

High

1036824

S4A4
Electrogenic sodium bicarbonate cotransporter 1

1

4

High-throughput

0.445

High

590882

TIMP2
Metalloproteinase inhibitor 2

1

2

High-throughput

0.437

High

767993

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1036736

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

7

High-throughput

0.437

High

1036740

DCA10
DDB1- and CUL4-associated factor 10

1

4

High-throughput

0.437

High

1036744

KPLCE
Protein KPLCE

1

1

High-throughput

0.437

High

1036760

ZCH18
Zinc finger CCCH domain-containing protein 18

1

5

High-throughput

0.437

High

1036766

SLX4
Structure-specific endonuclease subunit SLX4

1

3

High-throughput

0.437

High

1036774

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.437

High

213112

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.426

High

1036718

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.426

High

1016

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.407

High

1036711

LG3BP
Galectin-3-binding protein

1

3

High-throughput

0.407

High

1036767

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

6

High-throughput

0.407

High

1036783

MITOK
Mitochondrial potassium channel

2

0

High-throughput

0.328

High

325314

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

1036755

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

High-throughput

0.279

Low

1036784

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

1036804

TSSP
Thymus-specific serine protease

1

0

High-throughput

0.279

Low

377209

SOMA
Somatotropin

1

0

High-throughput

0.249

Low

1010596

DCD
Dermcidin

1

0

High-throughput

0.249

Low

1036792

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.249

Low

1036812

Q9NZ47
HCG1811444

1

0

High-throughput

0.249

Low

87433

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

653261

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025