HitPredict

Interactor 1: PLAK (P14923)
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene: JUP

Interactor 2: DSC1 (Q08554)
Desmocollin-1 (Cadherin family member 1) (Desmosomal glycoprotein 2/3) (DG2/DG3)
Gene: DSC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	24981860, 14673151
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001533 - cornified envelope GO:0005886 - plasma membrane GO:0030057 - desmosome GO:0070062 - extracellular exosome GO:0098609 - cell-cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 894
+	Mm
		580363 PLAK_MOUSE (1-745): 0: 552: 98.39		CADH2_MOUSE (23-890): 0: 733: 30.97
+	Hs
		577607 PLAK_HUMAN (1-745): 0: 550: 100.00		CADH2_HUMAN (23-890): 0: 734: 31.08
+	Gg
		205901 O42486_CHICK (1-731): 1.07e-174: 522: 67.51		CADH2_CHICK (22-890): 0: 735: 31.24
+	Hs
		764580 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		CADH4_HUMAN (23-890): 0: 742: 28.93
+	Rn
		1490147 CTNB1_RAT (1-731): 2.15e-172: 516: 67.38		CADH2_RAT (21-890): 0: 733: 31.13
+	Hs
		618223 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		CADH2_HUMAN (23-890): 0: 734: 31.08
+	Hs
		555850 PLAK_HUMAN (1-745): 0: 550: 100.00		CADH1_HUMAN (23-890): 0: 693: 29.24
+	Hs
		555906 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		CADH1_HUMAN (23-890): 0: 693: 29.24
+	Cl
		84231 CTNB1_CANLF (1-731): 3.56e-172: 515: 67.38		CADH1_CANLF (23-890): 0: 690: 29.98
+	Hs
		577640 PLAK_HUMAN (1-745): 0: 550: 100.00		DSG3_HUMAN (124-892): 0: 588: 28.30
+	Hs
		577616 PLAK_HUMAN (1-745): 0: 550: 100.00		CADH3_HUMAN (9-889): 0: 586: 26.33
+	Hs
		646699 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		CADH3_HUMAN (9-889): 0: 586: 26.33
+	Hs
		577937 PLAK_HUMAN (1-745): 0: 550: 100.00		CAD10_HUMAN (29-462): 2.44e-64: 233: 19.03
+	Hs
		764581 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		CADH6_HUMAN (31-462): 6.52e-68: 243: 20.00
+	Hs
		577680 PLAK_HUMAN (1-745): 0: 550: 100.00		CADH8_HUMAN (33-344): 7.59e-36: 148: 20.91
+	Hs
		577757 PLAK_HUMAN (1-745): 0: 550: 100.00		DSC3_HUMAN (1-331): 2.04e-28: 125: 12.75
+	Hs
		577720 PLAK_HUMAN (1-745): 0: 550: 100.00		DSC2_HUMAN (1-349): 1.69e-26: 118: 14.44
+	Hs
		764582 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		CADH8_HUMAN (33-344): 7.59e-36: 148: 20.91
+	Hs
		577752 PLAK_HUMAN (1-745): 0: 550: 100.00		DSG2_HUMAN (31-390): 3.22e-21: 102: 17.41
+	Hs
		764583 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		CAD11_HUMAN (30-236): 1.03e-15: 83.9: 15.25