HitPredict

Interactor 1: SET1 (Q5LJZ2)
Histone-lysine N-methyltransferase SETD1 (EC 2.1.1.354)
Gene: SET1

Interactor 2: RBBP5 (Q9VPH8)
Retinoblastoma-binding protein 5 homolog
Gene: RBBP5

Species: Drosophila melanogaster

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	21694722
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	N-SET~WD40
Common GO terms	GO:0048188 - Set1C/COMPASS complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1641 Dm			1 489
+	Dm
		1129076 SET1_DROME (1-1641): 0: 2298: 100.00		WDS_DROME (96-404): 2.6e-64: 214: 11.56
+	Mm
		876680 KMT2A_MOUSE (1109-1641): 2.16e-81: 301: 21.49		RBBP5_MOUSE (1-489): 4.91e-109: 335: 65.59
+	Hs
		975258 KMT2A_HUMAN (1127-1641): 3.09e-76: 284: 22.03		RBBP5_HUMAN (1-489): 4.31e-109: 335: 65.59
+	Hs
		165680 SET1A_HUMAN (1199-1641): 2.01e-74: 277: 40.22		RBBP5_HUMAN (1-489): 4.31e-109: 335: 65.59
+	Hs
		1070808 KMT2B_HUMAN (1275-1641): 3.52e-69: 260: 28.65		RBBP5_HUMAN (1-489): 4.31e-109: 335: 65.59
+	Sc
		755771 SET1_YEAST (1086-1641): 2.02e-75: 275: 25.71		SWD1_YEAST (1-355): 5.59e-101: 311: 29.74
+	Hs
		863447 EZH2_HUMAN (1099-1624): 1.96e-94: 325: 15.59		COPA_HUMAN (143-398): 2.06e-37: 148: 14.79
+	Hs
		1288291 SETD2_HUMAN (1097-1640): 6.27e-83: 305: 13.71		SNR40_HUMAN (142-402): 5.1e-42: 155: 9.78
+	Hs
		1080207 EZH2_HUMAN (1099-1624): 1.96e-94: 325: 15.59		FBXW7_HUMAN (181-390): 5.18e-28: 119: 10.23
+	Hs
		975304 KMT2A_HUMAN (1127-1641): 3.09e-76: 284: 22.03		SNR40_HUMAN (142-402): 5.1e-42: 155: 9.78
+	Hs
		1288387 KMT2B_HUMAN (1275-1641): 3.52e-69: 260: 28.65		SNR40_HUMAN (142-402): 5.1e-42: 155: 9.78
+	Hs
		331862 NSD2_HUMAN (1382-1640): 5.01e-67: 252: 22.43		SNR40_HUMAN (142-402): 5.1e-42: 155: 9.78
+	Hs
		975303 KMT2A_HUMAN (1127-1641): 3.09e-76: 284: 22.03		FBXW7_HUMAN (181-390): 5.18e-28: 119: 10.23
+	Hs
		1288292 NSD3_HUMAN (1398-1640): 6.97e-65: 245: 22.67		SNR40_HUMAN (142-402): 5.1e-42: 155: 9.78
+	Zm
		35725 A0A1D6M742_MAIZE (1044-1638): 2.46e-88: 306: 12.78		A0A1D6LQJ4_MAIZE (246-434): 3.67e-15: 78.5: 10.83
+	Hs
		903149 KMT2A_HUMAN (1127-1641): 3.09e-76: 284: 22.03		WDR5_HUMAN (234-399): 7.43e-22: 98.1: 12.72
+	Hs
		165657 SET1A_HUMAN (1199-1641): 2.01e-74: 277: 40.22		WDR5_HUMAN (234-399): 7.43e-22: 98.1: 12.72
+	Hs
		203735 SUV91_HUMAN (1288-1640): 1.21e-80: 274: 15.80		DAW1_HUMAN (212-399): 4.63e-19: 91.2: 9.69
+	Hs
		903604 KMT2B_HUMAN (1275-1641): 3.52e-69: 260: 28.65		WDR5_HUMAN (234-399): 7.43e-22: 98.1: 12.72
+	Hs
		903609 SET1B_HUMAN (27-310): 6.68e-62: 237: 25.90		WDR5_HUMAN (234-399): 7.43e-22: 98.1: 12.72