Protein: PLST
Plastin-3 (T-fimbrin) (T-plastin)

Gene: PLST, PLS3
Organism: Homo sapiens
Interactions: 157
UniProt ID: P13797

Gene Ontology (top 5):
GO:0005509 - calcium ion binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005884 - actin filament
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

568114

PLSL
Plastin-2

6

15

High-throughput

0.940

High

568239

PLSI
Plastin-1

4

17

High-throughput

0.895

High

568223

ACTB
Actin, cytoplasmic 1

2

20

High-throughput

0.754

High

568246

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

8

High-throughput

0.737

High

568259

FNDC5
Fibronectin type III domain-containing protein 5

1

2

High-throughput

0.691

High

568197

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

8

High-throughput

0.665

High

568237

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

8

High-throughput

0.665

High

568260

KLH23
Kelch-like protein 23

2

1

High-throughput

0.628

High

563104

CFTR
Cystic fibrosis transmembrane conductance regulator

3

10

High-throughput

0.624

High

568207

SYUA
Alpha-synuclein

1

3

High-throughput

0.621

High

156904

CTRO
Citron Rho-interacting kinase

1

18

High-throughput

0.618

High

362684

EGFR
Epidermal growth factor receptor

1

13

High-throughput

0.618

High

400217

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.618

High

411282

NTRK1
High affinity nerve growth factor receptor

1

17

High-throughput

0.618

High

541306

FGFR1
Fibroblast growth factor receptor 1

1

15

High-throughput

0.618

High

568196

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

20

High-throughput

0.618

High

568230

ACTG
Actin, cytoplasmic 2

1

20

High-throughput

0.618

High

568231

ACTC
Actin, alpha cardiac muscle 1

1

20

High-throughput

0.618

High

568236

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

8

High-throughput

0.618

High

568244

EPHA7
Ephrin type-A receptor 7

1

5

High-throughput

0.618

High

568253

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.618

High

568262

GA2L2
GAS2-like protein 2

1

10

High-throughput

0.618

High

568268

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

2

High-throughput

0.618

High

568271

RYR2
Ryanodine receptor 2

1

7

High-throughput

0.618

High

568285

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

16

High-throughput

0.618

High

568301

PD1L1
Programmed cell death 1 ligand 1

1

9

High-throughput

0.618

High

568311

NINL
Ninein-like protein

1

20

High-throughput

0.618

High

240631

PRKN
E3 ubiquitin-protein ligase parkin

2

9

High-throughput

0.584

High

184569

MK13
Mitogen-activated protein kinase 13

1

13

Small-scale

0.575

High

277882

SH3L1
Adapter SH3BGRL

2

2

High-throughput

0.571

High

395414

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

568240

HAPR1
HUWE1-associated protein modifying stress responses 1

2

0

High-throughput

0.559

High

568215

CDK9
Cyclin-dependent kinase 9

1

18

High-throughput

0.553

High

568278

LMTK3
Serine/threonine-protein kinase LMTK3

1

20

High-throughput

0.553

High

135472

DNM1L
Dynamin-1-like protein

1

5

High-throughput

0.536

High

161856

IMPA2
Inositol monophosphatase 2

1

1

High-throughput

0.536

High

568203

CCR1
C-C chemokine receptor type 1

1

7

High-throughput

0.536

High

568204

CNR2
Cannabinoid receptor 2

1

3

Small-scale

0.536

High

568210

MNDA
Myeloid cell nuclear differentiation antigen

1

2

High-throughput

0.536

High

568212

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.536

High

568263

RIN3
Ras and Rab interactor 3

1

7

High-throughput

0.536

High

568274

CUL5
Cullin-5

1

11

High-throughput

0.536

High

568289

P63
Tumor protein 63

1

3

Small-scale

0.536

High

185397

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

8

High-throughput

0.501

High

421418

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

484355

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

6

High-throughput

0.489

High

125197

LEG9
Galectin-9

1

3

High-throughput

0.479

High

217774

TGON2
Trans-Golgi network integral membrane protein 2

1

10

High-throughput

0.479

High

247643

NUPR1
Nuclear protein 1

1

7

High-throughput

0.479

High

315071

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

319356

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

324485

HEXI1
Protein HEXIM1

1

3

High-throughput

0.479

High

345317

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

425287

ISG15
Ubiquitin-like protein ISG15

1

14

High-throughput

0.479

High

461094

HS90A
Heat shock protein HSP 90-alpha

1

7

High-throughput

0.479

High

476073

ANXA5
Annexin A5

1

3

High-throughput

0.479

High

534575

BIP
Endoplasmic reticulum chaperone BiP

1

9

High-throughput

0.479

High

568194

EZRI
Ezrin

1

18

High-throughput

0.479

High

568198

CBL
E3 ubiquitin-protein ligase CBL

1

6

High-throughput

0.479

High

568202

STIP1
Stress-induced-phosphoprotein 1

1

10

High-throughput

0.479

High

568206

MSX2
Homeobox protein MSX-2

1

1

High-throughput

0.479

High

568209

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

568211

YAP1
Transcriptional coactivator YAP1

1

13

High-throughput

0.479

High

568213

TISD
mRNA decay activator protein ZFP36L2

1

1

High-throughput

0.479

High

568214

SOX2
Transcription factor SOX-2

1

10

High-throughput

0.479

High

568217

HDGF
Hepatoma-derived growth factor

1

3

High-throughput

0.479

High

568219

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

11

High-throughput

0.479

High

568221

TERA
Transitional endoplasmic reticulum ATPase

1

9

High-throughput

0.479

High

568224

UBC12
NEDD8-conjugating enzyme Ubc12

1

4

High-throughput

0.479

High

568225

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

3

High-throughput

0.479

High

568226

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

1

High-throughput

0.479

High

568227

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

9

High-throughput

0.479

High

568228

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.479

High

568232

EWS
RNA-binding protein EWS

1

7

High-throughput

0.479

High

568235

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

568238

NBR1
Next to BRCA1 gene 1 protein

1

2

High-throughput

0.479

High

568241

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

568242

KIF14
Kinesin-like protein KIF14

1

14

High-throughput

0.479

High

568243

IPYR
Inorganic pyrophosphatase

1

2

High-throughput

0.479

High

568245

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.479

High

568247

TET5C
Terminal nucleotidyltransferase 5C

1

1

High-throughput

0.479

High

568250

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.479

High

568254

SND1
Staphylococcal nuclease domain-containing protein 1

1

3

High-throughput

0.479

High

568258

RHG24
Rho GTPase-activating protein 24

1

10

High-throughput

0.479

High

568261

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

568265

BICD2
Protein bicaudal D homolog 2

1

20

High-throughput

0.479

High

568266

NUDC2
NudC domain-containing protein 2

1

6

High-throughput

0.479

High

568269

TOPB1
DNA topoisomerase 2-binding protein 1

1

13

High-throughput

0.479

High

568270

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

11

High-throughput

0.479

High

568273

ARHG2
Rho guanine nucleotide exchange factor 2

1

14

Small-scale

0.479

High

568277

FMNL2
Formin-like protein 2

1

2

High-throughput

0.479

High

568280

ATX2
Ataxin-2

1

12

Small-scale

0.479

High

568281

ANM1
Protein arginine N-methyltransferase 1

1

6

High-throughput

0.479

High

568282

H2B1M
Histone H2B type 1-M

1

8

High-throughput

0.479

High

568286

FACD2
Fanconi anemia group D2 protein

1

8

High-throughput

0.479

High

568287

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.479

High

568290

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

20

Small-scale

0.479

High

568291

TXNIP
Thioredoxin-interacting protein

1

5

Small-scale

0.479

High

568292

CHM4B
Charged multivesicular body protein 4b

1

20

High-throughput

0.479

High

568293

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

568294

ECT2
Protein ECT2

1

20

High-throughput

0.479

High

568295

ANLN
Anillin

1

13

High-throughput

0.479

High

568300

PIHD1
PIH1 domain-containing protein 1

1

3

High-throughput

0.479

High

568302

LUZP4
Leucine zipper protein 4

1

2

Small-scale

0.479

High

568303

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

1

High-throughput

0.479

High

568304

TRM7
tRNA

1

2

High-throughput

0.479

High

568305

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

568307

FAF1
FAS-associated factor 1

1

2

High-throughput

0.479

High

568309

PA2G4
Proliferation-associated protein 2G4

1

2

High-throughput

0.479

High

568313

LOXL2
Lysyl oxidase homolog 2

1

5

High-throughput

0.479

High

379852

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

446371

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

568201

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

568208

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

568216

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.458

High

568220

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

Small-scale

0.458

High

568272

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

High-throughput

0.458

High

568283

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

568297

SIAS
N-acetylneuraminate-9-phosphate synthase

1

0

High-throughput

0.458

High

568298

PHP14
14 kDa phosphohistidine phosphatase

1

0

High-throughput

0.458

High

261071

NSMA
Sphingomyelin phosphodiesterase 2

1

2

High-throughput

0.445

High

568218

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

7

Small-scale

0.445

High

568222

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

6

Small-scale

0.445

High

568229

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.445

High

568249

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.445

High

568288

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

9

High-throughput

0.445

High

568296

ITM2C
Integral membrane protein 2C

1

7

High-throughput

0.445

High

568299

DDX28
Probable ATP-dependent RNA helicase DDX28

1

3

High-throughput

0.445

High

568306

SPB13
Serpin B13

1

4

High-throughput

0.445

High

568310

GAB2
GRB2-associated-binding protein 2

1

14

High-throughput

0.445

High

297433

PIAS1
E3 SUMO-protein ligase PIAS1

1

5

High-throughput

0.437

High

471769

RU2B
U2 small nuclear ribonucleoprotein B''

1

5

High-throughput

0.437

High

568200

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

10

High-throughput

0.437

High

568205

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.437

High

568233

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

5

High-throughput

0.437

High

568248

DCA15
DDB1- and CUL4-associated factor 15

1

2

High-throughput

0.437

High

568251

PRP8
Pre-mRNA-processing-splicing factor 8

1

2

High-throughput

0.437

High

568255

MGDP1
Magnesium-dependent phosphatase 1

1

1

High-throughput

0.437

High

568308

TRI33
E3 ubiquitin-protein ligase TRIM33

1

11

High-throughput

0.437

High

568314

INSI2
Insulin-induced gene 2 protein

1

3

High-throughput

0.437

High

568195

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

568252

OLFM4
Olfactomedin-4

1

0

High-throughput

0.426

High

568256

S41A1
Solute carrier family 41 member 1

1

0

High-throughput

0.426

High

568276

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

568279

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.426

High

330030

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.407

High

344081

PTBP3
Polypyrimidine tract-binding protein 3

1

1

High-throughput

0.407

High

554145

BMP4
Bone morphogenetic protein 4

1

2

High-throughput

0.407

High

568199

HEMH
Ferrochelatase, mitochondrial

1

3

High-throughput

0.407

High

568257

SLX4
Structure-specific endonuclease subunit SLX4

1

9

High-throughput

0.407

High

568275

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.279

Low

254514

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low

568264

DJB14
DnaJ homolog subfamily B member 14

1

0

High-throughput

0.249

Low

568267

CN183
Putative uncharacterized protein encoded by LINC01599

1

0

High-throughput

0.249

Low

568312

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

568234

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

568284

RSRP1
Arginine/serine-rich protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025