HitPredict

Interactor 1: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Interactor 2: TBB1 (Q9H4B7)
Tubulin beta-1 chain
Gene: TUBB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	24275654
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005737 - cytoplasm GO:0070062 - extracellular exosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 2527 Hs			1 451
+	Hs
		1037252 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TBB3_HUMAN (1-450): 0: 711: 78.22
+	Hs
		428247 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TBB5_HUMAN (1-429): 0: 706: 79.95
+	Hs
		933841 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TBB4B_HUMAN (1-427): 0: 706: 80.33
+	Hs
		1130537 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TBB2B_HUMAN (1-430): 0: 705: 80.93
+	Hs
		1046482 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TBB2A_HUMAN (1-430): 0: 702: 80.70
+	Hs
		381221 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TBB4A_HUMAN (1-427): 0: 702: 80.33
+	Hs
		1130529 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TBB6_HUMAN (1-432): 0: 700: 79.63
+	Hs
		1130508 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TBA1C_HUMAN (1-439): 0: 685: 38.75
+	Mm
		1130127 LRRK2_MOUSE (1-2527): 0: 2865: 86.09		TBB4A_MOUSE (1-427): 0: 702: 80.33
+	Hs
		1037439 SHOC2_HUMAN (944-1353): 1.23e-60: 222: 22.27		TBB3_HUMAN (1-450): 0: 711: 78.22
+	Hs
		428238 LRRK1_HUMAN (771-1194): 2.3e-35: 151: 16.38		TBB5_HUMAN (1-429): 0: 706: 79.95
+	Hs
		933832 LRRK1_HUMAN (771-1194): 2.3e-35: 151: 16.38		TBB4B_HUMAN (1-427): 0: 706: 80.33
+	Hs
		201179 M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83		TBB5_HUMAN (1-429): 0: 706: 79.95
+	Hs
		201419 M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83		TBB2B_HUMAN (1-430): 0: 705: 80.93
+	Hs
		201171 M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83		TBB4A_HUMAN (1-427): 0: 702: 80.33