HitPredict

Interactor 1: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Interactor 2: WSB1 (Q9Y6I7)
WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box-containing WD protein SWiP-1)
Gene: WSB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	27273569
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0035556 - intracellular signal transduction
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 2527 Hs			1 421
+	Hs
		792995 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		LIS1_HUMAN (2-286): 2.98e-83: 262: 20.72
+	Hs
		1130429 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		SNR40_HUMAN (2-282): 1.31e-65: 215: 20.42
+	Hs
		48975 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		A0MNP2_HUMAN (2-282): 1.31e-65: 215: 20.42
+	Mm
		222644 LRRK2_MOUSE (1-2527): 0: 2865: 86.09		WSB1_MOUSE (1-420): 5.36e-96: 295: 89.60
+	Hs
		863455 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		COPA_HUMAN (206-381): 7.82e-34: 136: 18.54
+	Hs
		903286 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		WDR5_HUMAN (295-420): 1.65e-30: 121: 15.27
+	Hs
		1281479 SHOC2_HUMAN (944-1353): 1.23e-60: 222: 22.27		FBXW7_HUMAN (2-334): 4.09e-75: 249: 19.05
+	Hs
		201387 M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83		FBXW7_HUMAN (2-334): 4.09e-75: 249: 19.05
+	Hs
		201412 M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83		TBL1Y_HUMAN (286-418): 1.41e-17: 86.7: 14.38