HitPredict

Interactor 1: Q6GMD5 (Q6GMD5)
HECT-type E3 ubiquitin transferase (EC 2.3.2.26)
Gene: nedd4l.S

Interactor 2: SGK1A (Q6GPN6)
Serine/threonine-protein kinase Sgk1-A (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1-A)
Gene: sgk1-a

Species: Xenopus laevis

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.50	0.457

Property	Details
Experiments	15496163
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 971 Xl			1 434
+	Hs
		117024 NED4L_HUMAN (3-971): 0: 961: 88.35		SGK1_HUMAN (1-434): 7.42e-173: 492: 90.32
+	Mm
		1208292 NED4L_MOUSE (14-971): 0: 955: 89.90		SGK1_MOUSE (1-434): 3.46e-172: 490: 90.09
+	Hs
		1299664 NED4L_HUMAN (3-971): 0: 961: 88.35		AKT3_HUMAN (73-432): 5.65e-156: 451: 45.98
+	Hs
		681988 NED4L_HUMAN (3-971): 0: 961: 88.35		AKT1_HUMAN (28-429): 4.71e-154: 446: 41.58
+	Hs
		1285839 NED4L_HUMAN (3-971): 0: 961: 88.35		SGK3_HUMAN (29-431): 1.18e-152: 443: 66.91
+	Hs
		1299638 NED4L_HUMAN (3-971): 0: 961: 88.35		SGK2_HUMAN (69-428): 7.32e-151: 434: 69.72
+	Hs
		1299657 NED4L_HUMAN (3-971): 0: 961: 88.35		KS6B2_HUMAN (101-430): 1.16e-145: 425: 46.27
+	Mm
		93288 E9PXB7_MOUSE (119-971): 0: 808: 87.72		SGK1_MOUSE (1-434): 3.46e-172: 490: 90.09
+	Hs
		116984 NEDD4_HUMAN (97-971): 0: 756: 60.27		SGK1_HUMAN (1-434): 7.42e-173: 492: 90.32
+	Hs
		808324 NEDD4_HUMAN (97-971): 0: 756: 60.27		AKT3_HUMAN (73-432): 5.65e-156: 451: 45.98
+	Hs
		681731 NEDD4_HUMAN (97-971): 0: 756: 60.27		AKT1_HUMAN (28-429): 4.71e-154: 446: 41.58
+	Hs
		808277 NEDD4_HUMAN (97-971): 0: 756: 60.27		SGK2_HUMAN (69-428): 7.32e-151: 434: 69.72
+	Hs
		616684 NEDD4_HUMAN (97-971): 0: 756: 60.27		KS6B1_HUMAN (85-430): 4.9e-146: 427: 43.88
+	Hs
		1285838 ITCH_HUMAN (4-968): 0: 735: 31.91		SGK3_HUMAN (29-431): 1.18e-152: 443: 66.91
+	Hs
		568765 ITCH_HUMAN (4-968): 0: 735: 31.91		KAPCA_HUMAN (47-395): 2.37e-145: 419: 40.00
+	Hs
		808054 NEDD4_HUMAN (97-971): 0: 756: 60.27		KS6A3_HUMAN (38-371): 1.31e-108: 338: 25.22
+	Hs
		408640 HUWE1_HUMAN (247-969): 2.97e-165: 539: 28.72		KPCB_HUMAN (14-431): 4.41e-147: 435: 35.61
+	Hs
		784035 HUWE1_HUMAN (247-969): 2.97e-165: 539: 28.72		KPCI_HUMAN (36-430): 3.38e-146: 430: 35.78
+	Hs
		983863 HUWE1_HUMAN (247-969): 2.97e-165: 539: 28.72		KPCZ_HUMAN (62-430): 8.1e-96: 301: 39.26
+	Hs
		566484 SMUF1_HUMAN (13-379): 3.27e-29: 127: 14.39		KPCA_HUMAN (14-431): 5.97e-146: 432: 35.39