HitPredict

Interactor 1: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Interactor 2: SRMS (Q9H3Y6)
Tyrosine-protein kinase Srms (EC 2.7.10.2)
Gene: SRMS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	33961781, 32707033
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CDC37_M~PK_Tyr_Ser-Thr, CDC37_N~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 378 Hs			1 488
+	Hs
		557326 CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00		SRC_HUMAN (27-482): 0: 554: 40.86
+	Hs
		463108 CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00		YES_HUMAN (3-482): 0: 551: 39.06
+	Hs
		440577 CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00		FYN_HUMAN (7-482): 0: 550: 38.43
+	Hs
		486697 CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00		FGR_HUMAN (1-482): 0: 542: 40.24
+	Hs
		473427 CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00		HCK_HUMAN (26-486): 0: 540: 40.30
+	Hs
		440092 CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00		LCK_HUMAN (42-483): 0: 527: 42.22
+	Hs
		463542 CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00		LYN_HUMAN (1-486): 2.73e-179: 514: 36.03
+	Hs
		902840 CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00		BLK_HUMAN (2-486): 2.73e-179: 513: 39.68
+	Hs
		840963 CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00		ABL2_HUMAN (20-486): 1.32e-168: 508: 36.42
+	Hs
		1065084 CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00		ITK_HUMAN (7-486): 9.4e-164: 478: 33.27
+	Hs
		1158352 CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00		Q573B4_HUMAN (1-483): 1.97e-163: 473: 35.89
+	Hs
		1054114 CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00		BTK_HUMAN (7-478): 5.42e-161: 472: 32.93
+	Hs
		1118406 CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00		PTK6_HUMAN (45-483): 6.08e-164: 472: 45.29
+	Dm
		362496 CDC37_DROME (1-351): 1.29e-126: 371: 52.54		SRC64_DROME (22-483): 1.13e-173: 501: 39.09