HitPredict

Interactor 1: TRAF7 (Q6Q0C0)
E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.-) (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7)
Gene: TRAF7

Interactor 2: M4K5 (Q9Y4K4)
Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5)
Gene: MAP4K5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 670 Hs			1 846
+	Hs
		1163009 TRAF7_HUMAN (1-670): 1.55e-180: 530: 100.00		M4K3_HUMAN (7-846): 0: 940: 64.55
+	Hs
		1272883 FBXW7_HUMAN (70-499): 3.77e-45: 173: 12.60		M4K1_HUMAN (9-845): 0: 774: 44.52
+	Sc
		419809 NLE1_YEAST (380-669): 2.43e-72: 244: 23.53		SNF1_YEAST (7-561): 1.99e-132: 410: 17.35
+	Dm
		90543 Q9VDE3_DROME (181-591): 1.74e-61: 215: 14.77		E1JGN0_DROME (4-616): 3.67e-136: 435: 18.02
+	Hs
		682082 FBW1A_HUMAN (175-586): 2.32e-60: 214: 15.99		AKT1_HUMAN (12-346): 6.18e-125: 386: 22.38
+	Hs
		1023143 FBW1A_HUMAN (175-586): 2.32e-60: 214: 15.99		STK4_HUMAN (10-278): 1.36e-120: 375: 45.93
+	Hs
		1027457 FBW1A_HUMAN (175-586): 2.32e-60: 214: 15.99		STK3_HUMAN (1-408): 2.41e-120: 374: 32.45
+	Hs
		1023136 FBW1B_HUMAN (181-586): 1.61e-59: 210: 15.51		STK4_HUMAN (10-278): 1.36e-120: 375: 45.93
+	Hs
		1027451 FBW1B_HUMAN (181-586): 1.61e-59: 210: 15.51		STK3_HUMAN (1-408): 2.41e-120: 374: 32.45
+	Dm
		1249839 Q9VDE3_DROME (181-591): 1.74e-61: 215: 14.77		HIPPO_DROME (8-456): 3.44e-113: 361: 30.90
+	Hs
		681967 FBXW7_HUMAN (70-499): 3.77e-45: 173: 12.60		AKT1_HUMAN (12-346): 6.18e-125: 386: 22.38
+	Hs
		1027412 FBXW7_HUMAN (70-499): 3.77e-45: 173: 12.60		STK3_HUMAN (1-408): 2.41e-120: 374: 32.45
+	Hs
		1038897 WDR5B_HUMAN (100-464): 4.85e-24: 105: 11.73		KCC2B_HUMAN (8-488): 3.68e-127: 398: 22.27
+	Dm
		1249851 FBXW7_DROME (10-475): 2.16e-34: 142: 13.09		HIPPO_DROME (8-456): 3.44e-113: 361: 30.90
+	Mm
		949357 TBL1R_MOUSE (424-669): 4.14e-51: 187: 19.64		TNIK_MOUSE (14-295): 1.14e-72: 262: 45.73
+	Hs
		324857 FBXW7_HUMAN (70-499): 3.77e-45: 173: 12.60		M4K4_HUMAN (2-295): 4.04e-64: 236: 43.51
+	Hs
		793038 LIS1_HUMAN (140-426): 1.68e-23: 105: 10.82		TNIK_HUMAN (14-295): 1.26e-72: 262: 45.73
+	Mm
		949365 TAF5_MOUSE (161-427): 2.56e-21: 100: 11.23		TNIK_MOUSE (14-295): 1.14e-72: 262: 45.73