Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3
Interactor 2: NEDD8 (Q15843)
Ubiquitin-like protein NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8)
Gene: NEDD8
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.973 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 33961781, 34878901, 35563538, 37495603, 37788672, 40437099, 21145461, 17192413, 16503656, 34591642, 18274552 |
| Identification Methods | affinity chromatography technology, cross-linking study, two hybrid, tandem affinity purification, anti tag coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Cullin~ubiquitin, Cullin_Nedd8~ubiquitin |
| Common GO terms | GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process and 4 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
