HitPredict

Interactor 1: PK1 (Q17850)
Serine/threonine-protein kinase pak-1 (EC 2.7.11.1) (CePAK) (p21-activated kinase 1) (PAK1)
Gene: pak-1

Interactor 2: Q19739 (Q19739)
CHp/Wrch Rho-like protein homolog
Gene: chw-1

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	31462781
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005525 - GTP binding GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 572 Ce			1 207
+	Ce
		1041910 PK1_CAEEL (1-572): 0: 551: 100.00		RAC1_CAEEL (8-181): 1.11e-86: 255: 46.20
+	Mm
		109226 G5E884_MOUSE (5-568): 1.43e-166: 486: 53.07		RAC2_MOUSE (8-182): 3.67e-86: 254: 44.87
+	Hs
		297095 PAK3_HUMAN (1-570): 5.58e-169: 492: 52.72		CDC42_HUMAN (8-182): 1.17e-83: 247: 45.41
+	Hs
		581018 PAK1_HUMAN (6-568): 4.27e-166: 485: 53.16		RAC2_HUMAN (8-182): 1.95e-86: 254: 44.87
+	Hs
		953420 PAK1_HUMAN (6-568): 4.27e-166: 485: 53.16		RAC3_HUMAN (8-173): 7.47e-86: 253: 47.16
+	Hs
		1015406 PAK1_HUMAN (6-568): 4.27e-166: 485: 53.16		RHOG_HUMAN (8-183): 9.52e-84: 248: 40.32
+	Mm
		109224 G5E884_MOUSE (5-568): 1.43e-166: 486: 53.07		CDC42_MOUSE (8-182): 1.17e-83: 247: 45.41
+	Rn
		771651 PAK1_RAT (6-568): 2.45e-166: 485: 53.16		CDC42_RAT (8-182): 1.17e-83: 247: 45.41
+	Hs
		955115 PAK1_HUMAN (6-568): 4.27e-166: 485: 53.16		CDC42_HUMAN (8-182): 1.17e-83: 247: 45.41
+	Hs
		297098 PAK3_HUMAN (1-570): 5.58e-169: 492: 52.72		RAC1_HUMAN (10-182): 2.27e-76: 229: 46.45
+	Mm
		109225 G5E884_MOUSE (5-568): 1.43e-166: 486: 53.07		RAC1_MOUSE (10-182): 2.27e-76: 229: 46.45
+	Hs
		988330 PAK1_HUMAN (6-568): 4.27e-166: 485: 53.16		RAC1_HUMAN (10-182): 2.27e-76: 229: 46.45
+	Ce
		1050327 PK1_CAEEL (1-572): 0: 551: 100.00		CDC42_CAEEL (8-182): 5.87e-49: 159: 44.32
+	Hs
		297108 PAK3_HUMAN (1-570): 5.58e-169: 492: 52.72		RHOU_HUMAN (10-181): 4.93e-60: 190: 51.10
+	Hs
		1096454 PAK1_HUMAN (6-568): 4.27e-166: 485: 53.16		RHOU_HUMAN (10-181): 4.93e-60: 190: 51.10
+	Hs
		1096479 PAK1_HUMAN (6-568): 4.27e-166: 485: 53.16		RHOV_HUMAN (10-184): 2.32e-58: 185: 50.00
+	Hs
		297118 PAK3_HUMAN (1-570): 5.58e-169: 492: 52.72		RHOJ_HUMAN (5-192): 1.86e-45: 151: 40.40
+	Mm
		109234 G5E884_MOUSE (5-568): 1.43e-166: 486: 53.07		RHOQ_MOUSE (10-182): 9.89e-46: 152: 43.72
+	Hs
		1096499 PAK1_HUMAN (6-568): 4.27e-166: 485: 53.16		RHOJ_HUMAN (5-192): 1.86e-45: 151: 40.40
+	Hs
		601265 PAK1_HUMAN (6-568): 4.27e-166: 485: 53.16		RHOQ_HUMAN (10-182): 1.58e-45: 151: 43.17