HitPredict

Interactor 1: ARK2C (Q6ZSG1)
E3 ubiquitin-protein ligase ARK2C (EC 2.3.2.27) (RING finger protein 165) (RNF165)
Gene: ARK2C

Interactor 2: UBE2W (Q96B02)
Ubiquitin-conjugating enzyme E2 W (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme W) (N-terminal E2 ubiquitin-conjugating enzyme) (EC 2.3.2.25) (N-terminus-conjugating E2) (Ubiquitin carrier protein W) (Ubiquitin-conjugating enzyme 16) (UBC-16) (Ubiquitin-protein ligase W)
Gene: UBE2W

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19690564
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 346 Hs			1 151
+	Hs
		1170316 ARK2C_HUMAN (1-346): 5.82e-87: 267: 100.00		UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37
+	Hs
		849350 ARK2C_HUMAN (1-346): 5.82e-87: 267: 100.00		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		919759 ARK2C_HUMAN (1-346): 5.82e-87: 267: 100.00		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		895822 ARK2C_HUMAN (1-346): 5.82e-87: 267: 100.00		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		1170314 ARK2C_HUMAN (1-346): 5.82e-87: 267: 100.00		UB2E3_HUMAN (1-150): 1.13e-65: 200: 35.33
+	Hs
		851829 ARK2C_HUMAN (1-346): 5.82e-87: 267: 100.00		UB2E1_HUMAN (1-150): 3.64e-64: 196: 34.00
+	Hs
		1169203 RN111_HUMAN (22-346): 2.93e-43: 161: 39.03		UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37
+	Hs
		849348 RN111_HUMAN (22-346): 2.93e-43: 161: 39.03		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	At
		715139 RHG1A_ARATH (15-336): 5.8e-44: 162: 19.14		UBC9_ARATH (4-150): 2.28e-68: 205: 32.65
+	At
		715158 RHG1A_ARATH (15-336): 5.8e-44: 162: 19.14		UBC11_ARATH (4-150): 1.75e-68: 205: 33.33
+	Hs
		919758 RN111_HUMAN (22-346): 2.93e-43: 161: 39.03		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		895821 RN111_HUMAN (22-346): 2.93e-43: 161: 39.03		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		1169179 RN111_HUMAN (22-346): 2.93e-43: 161: 39.03		UB2E2_HUMAN (1-150): 3.17e-66: 201: 34.67
+	Hs
		1169175 RN111_HUMAN (22-346): 2.93e-43: 161: 39.03		UB2E3_HUMAN (1-150): 1.13e-65: 200: 35.33
+	Hs
		851828 RN111_HUMAN (22-346): 2.93e-43: 161: 39.03		UB2E1_HUMAN (1-150): 3.64e-64: 196: 34.00
+	Hs
		1169176 RN111_HUMAN (22-346): 2.93e-43: 161: 39.03		UBE2W_HUMAN (1-151): 1.05e-62: 190: 100.00
+	Hs
		865028 TTC3_HUMAN (27-344): 4.23e-33: 132: 11.56		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		865068 TTC3_HUMAN (27-344): 4.23e-33: 132: 11.56		UB2E3_HUMAN (1-150): 1.13e-65: 200: 35.33
+	At
		715137 RNG1L_ARATH (114-343): 1.95e-29: 117: 13.99		UBC9_ARATH (4-150): 2.28e-68: 205: 32.65
+	At
		1228275 RNG1L_ARATH (114-343): 1.95e-29: 117: 13.99		UBC29_ARATH (4-150): 2.73e-66: 200: 30.61