HitPredict

Interactor 1: ORC5 (Q24169)
Origin recognition complex subunit 5
Gene: ORC5

Interactor 2: Q9VSM9 (Q9VSM9)
Cell division control protein
Gene: Cdc6

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	32848132, 29899147
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003688 - DNA replication origin binding GO:0005634 - nucleus GO:0006270 - DNA replication initiation GO:0016887 - ATP hydrolysis activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 460 Dm			1 662
+	Dm
		195734 ORC5_DROME (1-460): 3.71e-174: 498: 100.00		ORC1_DROME (12-650): 1.4e-114: 367: 20.64
+	Hs
		230918 ORC5_HUMAN (7-460): 1.54e-148: 431: 34.69		CDC6_HUMAN (87-655): 7.14e-143: 429: 32.09
+	Hs
		230899 ORC5_HUMAN (7-460): 1.54e-148: 431: 34.69		ORC1_HUMAN (6-647): 6.13e-134: 416: 21.11
+	At
		1232310 ORC5_ARATH (6-457): 3.07e-110: 337: 22.14		ORC1B_ARATH (32-651): 9e-146: 445: 18.58
+	Dm
		1172752 ORC5_DROME (1-460): 3.71e-174: 498: 100.00		Q9W102_DROME (246-656): 1.1e-73: 246: 13.28
+	Hs
		230854 ORC5_HUMAN (7-460): 1.54e-148: 431: 34.69		ORC4_HUMAN (230-658): 1.3e-91: 292: 14.89
+	Dm
		195740 ORC1_DROME (5-251): 1.09e-55: 200: 15.89		Q9VSM9_DROME (1-662): 4.63e-176: 518: 100.00
+	Sc
		898169 ORC5_YEAST (10-458): 3.67e-115: 348: 21.93		ORC1_YEAST (22-653): 2.02e-107: 348: 16.88
+	Sp
		207353 ORC5_SCHPO (4-456): 1.67e-111: 338: 23.90		ORC1_SCHPO (154-653): 3.68e-108: 344: 21.93
+	Sp
		207352 ORC5_SCHPO (4-456): 1.67e-111: 338: 23.90		CDC18_SCHPO (97-650): 2.82e-101: 322: 25.00
+	Hs
		1406946 CDC6_HUMAN (4-246): 4.05e-65: 221: 17.60		CDC6_HUMAN (87-655): 7.14e-143: 429: 32.09
+	Hs
		1104326 CDC6_HUMAN (4-246): 4.05e-65: 221: 17.60		ORC1_HUMAN (6-647): 6.13e-134: 416: 21.11
+	Sc
		479272 ORC5_YEAST (10-458): 3.67e-115: 348: 21.93		CDC6_YEAST (184-620): 4.13e-80: 265: 22.06
+	Sp
		207356 ORC5_SCHPO (4-456): 1.67e-111: 338: 23.90		ORC4_SCHPO (20-607): 2.19e-76: 265: 12.72
+	At
		1232309 ORC5_ARATH (6-457): 3.07e-110: 337: 22.14		ORC4_ARATH (243-654): 4.64e-74: 246: 16.05
+	Hs
		230853 ORC5_HUMAN (7-460): 1.54e-148: 431: 34.69		ORC5_HUMAN (262-449): 1.09e-33: 135: 16.34
+	Sc
		898171 ORC5_YEAST (10-458): 3.67e-115: 348: 21.93		ORC4_YEAST (205-617): 3.6e-61: 214: 13.29
+	Dm
		195742 ORC1_DROME (5-251): 1.09e-55: 200: 15.89		Q9W102_DROME (246-656): 1.1e-73: 246: 13.28