Protein: ORC5
Origin recognition complex subunit 5

Gene: ORC5
Organism: Homo sapiens
Interactions: 86
UniProt ID: O43913

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0000781 - chromosome, telomeric region
GO:0000785 - chromatin
GO:0000808 - origin recognition complex
GO:0003688 - DNA replication origin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

230900

ORC2
Origin recognition complex subunit 2

12

18

Small-scale

0.982

High

230899

ORC1
Origin recognition complex subunit 1

8

19

Small-scale

0.969

High

230854

ORC4
Origin recognition complex subunit 4

7

19

Small-scale

0.953

High

230925

ORC3
Origin recognition complex subunit 3

6

18

Small-scale

0.945

High

230872

MCM3
DNA replication licensing factor MCM3

2

20

Small-scale

0.793

High

230884

MCM2
DNA replication licensing factor MCM2

2

20

Small-scale

0.793

High

230853

ORC5
Origin recognition complex subunit 5

2

18

Small-scale

0.767

High

230877

MCM5
DNA replication licensing factor MCM5

1

20

High-throughput

0.692

High

230918

CDC6
Cell division control protein 6 homolog

1

19

High-throughput

0.692

High

230858

SCN2B
Sodium channel regulatory subunit beta-2

4

3

High-throughput

0.630

High

230876

MCM4
DNA replication licensing factor MCM4

1

20

Small-scale

0.621

High

230878

MCM7
DNA replication licensing factor MCM7

1

20

Small-scale

0.621

High

230927

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

2

3

Small-scale

0.611

High

230870

DPEP1
Dipeptidase 1

2

0

High-throughput

0.602

High

230917

CDC5L
Cell division cycle 5-like protein

2

4

High-throughput

0.595

High

230930

ORC6
Origin recognition complex subunit 6

2

9

Small-scale

0.594

High

230856

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.584

High

230868

LAMP2
Lysosome-associated membrane glycoprotein 2

2

3

High-throughput

0.574

High

230880

APJ
Apelin receptor

2

2

High-throughput

0.574

High

230881

VIPR2
Vasoactive intestinal polypeptide receptor 2

2

1

High-throughput

0.574

High

230902

I13R2
Interleukin-13 receptor subunit alpha-2

2

2

High-throughput

0.574

High

230905

C3AR
C3a anaphylatoxin chemotactic receptor

2

3

High-throughput

0.574

High

230865

ESR1
Estrogen receptor

2

6

High-throughput

0.571

High

230888

H4
Histone H4

2

8

High-throughput

0.563

High

230909

OBI1
ORC ubiquitin ligase 1

1

1

Small-scale

0.561

High

230903

NONO
Non-POU domain-containing octamer-binding protein

1

3

High-throughput

0.541

High

132415

CDC7
Cell division cycle 7-related protein kinase

1

7

High-throughput

0.536

High

230859

CDC45
Cell division control protein 45 homolog

1

1

High-throughput

0.536

High

74401

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

1

High-throughput

0.536

High

230864

GLPA
Glycophorin-A

1

1

High-throughput

0.536

High

230916

TCPQM
T-complex protein 1 subunit theta-like 2

1

2

High-throughput

0.536

High

173784

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.513

High

230860

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

1

Small-scale

0.501

High

230882

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

2

High-throughput

0.501

High

230928

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

164882

TR10C
Tumor necrosis factor receptor superfamily member 10C

1

7

High-throughput

0.489

High

208929

CYB5B
Cytochrome b5 type B

1

1

High-throughput

0.489

High

230875

CD80
T-lymphocyte activation antigen CD80

1

4

High-throughput

0.489

High

230886

CXCR4
C-X-C chemokine receptor type 4

1

2

High-throughput

0.489

High

230896

VMAT2
Synaptic vesicular amine transporter

1

5

High-throughput

0.489

High

230869

RFA2
Replication protein A 32 kDa subunit

1

3

Small-scale

0.481

High

230898

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

1

High-throughput

0.481

High

230911

TAXB1
Tax1-binding protein 1

1

3

High-throughput

0.481

High

230919

NIF3L
NIF3-like protein 1

1

1

High-throughput

0.481

High

230921

UBQL4
Ubiquilin-4

1

2

High-throughput

0.481

High

230926

DBF4A
Protein DBF4 homolog A

1

2

Small-scale

0.481

High

230887

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

Small-scale

0.480

High

230862

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

4

High-throughput

0.479

High

230863

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

230873

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

230879

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

230889

H2B1C
Histone H2B type 1-C/E/F/G/I

1

10

High-throughput

0.479

High

230891

H31
Histone H3.1

1

9

High-throughput

0.479

High

230892

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

230894

H33
Histone H3.3

1

9

High-throughput

0.479

High

230901

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.479

High

230913

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

230914

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

230915

CIC
Protein capicua homolog

1

3

High-throughput

0.479

High

230867

K1C18
Keratin, type I cytoskeletal 18

1

0

High-throughput

0.460

High

230908

DMRTA
Doublesex- and mab-3-related transcription factor A1

1

0

High-throughput

0.460

High

230857

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

230871

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

230890

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

230904

KS6A1
Ribosomal protein S6 kinase alpha-1

1

0

High-throughput

0.458

High

230907

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

230923

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

230866

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

230897

DDR1
Epithelial discoidin domain-containing receptor 1

1

1

Small-scale

0.445

High

230885

LAMB2
Laminin subunit beta-2

1

3

High-throughput

0.439

High

230922

STAB1
Stabilin-1

1

1

High-throughput

0.439

High

230920

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

230855

PRKY
Putative serine/threonine-protein kinase PRKY

1

0

High-throughput

0.426

High

230883

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

230906

H31T
Histone H3.1t

1

9

High-throughput

0.408

High

230861

LYPD3
Ly6/PLAUR domain-containing protein 3

3

0

High-throughput

0.347

High

230912

TM171
Transmembrane protein 171

3

0

High-throughput

0.347

High

60694

F234B
Protein FAM234B

2

0

High-throughput

0.328

High

230874

CD70
CD70 antigen

2

0

High-throughput

0.328

High

71183

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

230893

X3CL1
Fractalkine

1

0

High-throughput

0.279

Low

230895

TNR17
Tumor necrosis factor receptor superfamily member 17

1

0

High-throughput

0.279

Low

230929

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low

230910

TXD11
Thioredoxin domain-containing protein 11

1

0

High-throughput

0.251

Low

230924

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025