Protein: CDC6
Cell division control protein 6

Gene: CDC6
Organism: Saccharomyces cerevisiae S288C
Interactions: 51
UniProt ID: P09119

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0003682 - chromatin binding
GO:0003688 - DNA replication origin binding
GO:0003924 - GTPase activity
GO:0004861 - cyclin-dependent protein serine/threonine kinase inhibitor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

479258

ORC2
Origin recognition complex subunit 2

8

14

Small-scale

0.963

High

479274

ORC1
Origin recognition complex subunit 1

6

16

Small-scale

0.949

High

479276

ORC4
Origin recognition complex subunit 4

5

16

Small-scale

0.912

High

479275

ORC3
Origin recognition complex subunit 3

4

2

Small-scale

0.885

High

479262

ORC6
Origin recognition complex subunit 6

3

2

Small-scale

0.840

High

479251

MCM3
DNA replication licensing factor MCM3

2

20

Small-scale

0.768

High

364243

CDK1
Cyclin-dependent kinase 1

13

11

Small-scale

0.761

High

479260

PRS7
26S proteasome regulatory subunit 7 homolog

2

0

High-throughput

0.761

High

460700

CDC4
Cell division control protein 4

8

3

Small-scale

0.743

High

479272

ORC5
Origin recognition complex subunit 5

6

14

Small-scale

0.726

High

479254

MCM2
DNA replication licensing factor MCM2

5

20

Small-scale

0.722

High

479252

CG22
G2/mitotic-specific cyclin-2

5

9

Small-scale

0.711

High

479278

CDC14
Tyrosine-protein phosphatase CDC14

3

2

Small-scale

0.670

High

479247

CKS1
Cyclin-dependent kinases regulatory subunit

3

1

Small-scale

0.641

High

479248

MCK1
Protein kinase MCK1

2

4

Small-scale

0.636

High

479256

IME2
Meiosis induction protein kinase IME2/SME1

2

13

Small-scale

0.625

High

479268

LSB3
LAS seventeen-binding protein 3

2

2

High-throughput

0.619

High

479261

MCM7
DNA replication licensing factor MCM7

2

19

Small-scale

0.602

High

479270

CDT1
Cell division cycle protein CDT1

2

2

Small-scale

0.602

High

479281

CAB5
Dephospho-CoA kinase CAB5

2

0

High-throughput

0.563

High

479273

IPI3
Pre-rRNA-processing protein IPI3

1

1

Small-scale

0.552

High

479264

RV167
Reduced viability upon starvation protein 167

1

2

High-throughput

0.541

High

479249

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

1

1

Small-scale

0.501

High

479250

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

1

Small-scale

0.501

High

479279

IMA1
Importin subunit alpha

1

2

Small-scale

0.501

High

479257

YSC84
Protein YSC84

1

2

High-throughput

0.494

High

479243

HSF
Heat shock transcription factor

1

0

High-throughput

0.493

High

479245

ABF1
ARS-binding factor 1

1

0

Small-scale

0.480

High

479246

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

1

0

Small-scale

0.480

High

479241

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

479242

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

479253

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

479255

MCM5
Minichromosome maintenance protein 5

1

20

Small-scale

0.479

High

479280

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

Small-scale

0.479

High

479263

ECM1
Shuttling pre-60S factor ECM1

1

0

Small-scale

0.460

High

479266

PP4R3
Serine/threonine-protein phosphatase 4 regulatory subunit 3

1

0

Small-scale

0.460

High

479282

ECM11
Protein ECM11

1

0

Small-scale

0.460

High

479284

RFM1
Repression factor of MSEs protein 1

1

0

Small-scale

0.460

High

479271

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

479277

2ABA
Protein phosphatase PP2A regulatory subunit B

1

0

Small-scale

0.458

High

479283

DIA2
Protein DIA2

1

0

Small-scale

0.458

High

479244

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

383428

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

433356

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

479239

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

479240

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

479259

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

479267

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.426

High

479269

BBC1
Myosin tail region-interacting protein MTI1

1

0

High-throughput

0.282

High

479285

SEC39
Protein transport protein SEC39

1

0

High-throughput

0.279

Low

479265

GET2
Golgi to ER traffic protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025