HitPredict

Interactor 1: EMSY (Q7Z589)
BRCA2-interacting transcriptional repressor EMSY
Gene: EMSY

Interactor 2: ASH2L (Q9UBL3)
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)
Gene: ASH2L

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	34079125, 19131338
Identification Methods	proximity labelling technology, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1322 Hs			1 628
+	Hs
		1057010 MDC1_HUMAN (94-1250): 3.69e-25: 116: 10.96		ASH2L_HUMAN (1-628): 0: 790: 100.00
+	Hs
		1170094 SRCAP_HUMAN (588-1312): 6.01e-16: 86: 9.66		ASH2L_HUMAN (1-628): 0: 790: 100.00
+	Hs
		1264814 TITIN_HUMAN (94-1299): 1.78e-13: 78.2: 9.72		ASH2L_HUMAN (1-628): 0: 790: 100.00
+	Hs
		1243848 KMT2C_HUMAN (136-1005): 1.04e-12: 75.6: 6.91		ASH2L_HUMAN (1-628): 0: 790: 100.00
+	Hs
		152695 KMT2D_HUMAN (261-1253): 1.13e-12: 75.2: 7.65		ASH2L_HUMAN (1-628): 0: 790: 100.00
+	Mm
		93468 SPEG_MOUSE (227-1293): 2.72e-12: 74.1: 8.20		RYR2_MOUSE (215-602): 1.46e-81: 283: 13.74
+	Dm
		1097991 Q9VLS7_DROME (186-1322): 1.42e-23: 111: 9.73		RYR_DROME (202-578): 2.13e-63: 230: 16.32
+	Hs
		601670 TITIN_HUMAN (94-1299): 1.78e-13: 78.2: 9.72		RYR1_HUMAN (215-602): 1.07e-73: 260: 15.33
+	Hs
		1056849 MDC1_HUMAN (94-1250): 3.69e-25: 116: 10.96		HNRL2_HUMAN (270-581): 8.58e-54: 198: 19.41
+	Hs
		1301797 MUC5B_HUMAN (61-1062): 4.61e-18: 93.3: 9.50		RANB9_HUMAN (346-580): 6.91e-47: 178: 22.18
+	Hs
		962178 HUWE1_HUMAN (272-823): 7.43e-11: 69.4: 14.11		HNRPU_HUMAN (301-600): 3.43e-52: 194: 20.74
+	Hs
		1192139 HUWE1_HUMAN (272-823): 7.43e-11: 69.4: 14.11		DDX1_HUMAN (355-623): 2.2e-51: 191: 19.27