Interactor 1: TLR4 (O00206)
Toll-like receptor 4 (hToll) (CD antigen CD284)
Gene: TLR4
Interactor 2: TIRAP (P58753)
Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein) (MyD88-2)
Gene: TIRAP
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.96 | 0.60 | 0.761 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 17258210, 18221795, 20048342, 11526399, 11544529, 21903422, 14517278, 19717524, 21873236, 22139835, 21829704, 24265315 |
| Identification Methods | protein complementation assay, affinity chromatography technology, pull down, anti tag coimmunoprecipitation, two hybrid, mammalian protein protein interaction trap |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0002755 - MyD88-dependent toll-like receptor signaling pathway GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0006954 - inflammatory response GO:0009986 - cell surface and 14 others more... |
| Homologous interactions | 3 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
