HitPredict

Interactor 1: Q5U0Y0 (Q5U0Y0)
Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)
Gene: Sin3A

Interactor 2: Q9VWG2 (Q9VWG2)
FI07430p (Uncharacterized protein, isoform A) (Uncharacterized protein, isoform B)
Gene: SDS3

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	20566628, 22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PAH~Sds3, Sds3~Sin3_corepress, Sds3~Sin3a_C
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0070822 - Sin3-type complex
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 2062 Dm			1 327
+	Dm
		1216755 Q5U0Y0_DROME (1-2062): 0: 1903: 100.00		Q9VYI2_DROME (16-254): 1.23e-82: 252: 23.85
+	Hs
		1208634 SIN3A_HUMAN (172-680): 4.58e-51: 201: 20.85		BRM1L_HUMAN (17-325): 2.6e-109: 322: 26.94
+	Mm
		1221132 SIN3A_MOUSE (172-680): 4.78e-52: 204: 20.66		SDS3_MOUSE (24-327): 1.88e-96: 290: 40.52
+	Hs
		1403022 SIN3A_HUMAN (172-680): 4.58e-51: 201: 20.85		SDS3_HUMAN (24-327): 1.27e-96: 290: 40.85
+	Hs
		274339 SIN3B_HUMAN (260-700): 5.34e-35: 148: 17.65		BRM1L_HUMAN (17-325): 2.6e-109: 322: 26.94
+	Mm
		1223811 SIN3B_MOUSE (260-1057): 6.04e-39: 161: 14.68		SDS3_MOUSE (24-327): 1.88e-96: 290: 40.52
+	Hs
		274382 SIN3B_HUMAN (260-700): 5.34e-35: 148: 17.65		SDS3_HUMAN (24-327): 1.27e-96: 290: 40.85
+	Hs
		1403026 SIN3A_HUMAN (172-680): 4.58e-51: 201: 20.85		BRMS1_HUMAN (40-230): 3.66e-71: 222: 24.48
+	Hs
		1129751 MDC1_HUMAN (15-582): 2.73e-19: 97.9: 8.45		SDS3_HUMAN (24-327): 1.27e-96: 290: 40.85
+	Hs
		274384 SIN3B_HUMAN (260-700): 5.34e-35: 148: 17.65		BRMS1_HUMAN (40-230): 3.66e-71: 222: 24.48