HitPredict

Interactor 1: MRCKA (Q5VT25)
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)
Gene: CDC42BPA

Interactor 2: RHOV (Q96L33)
Rho-related GTP-binding protein RhoV (CDC42-like GTPase 2) (GTP-binding protein-like 2) (Rho GTPase-like protein ARHV) (Wnt-1 responsive Cdc42 homolog 2) (WRCH-2)
Gene: RHOV

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1732 Hs			1 236
+	Hs
		1217532 MRCKA_HUMAN (1-1732): 0: 1630: 100.00		RHOU_HUMAN (32-236): 2.91e-89: 265: 60.48
+	Hs
		988432 MRCKA_HUMAN (1-1732): 0: 1630: 100.00		RAC1_HUMAN (32-217): 7.38e-78: 234: 53.23
+	Hs
		601324 MRCKA_HUMAN (1-1732): 0: 1630: 100.00		RHOQ_HUMAN (23-236): 1.98e-75: 228: 50.00
+	Hs
		953499 MRCKA_HUMAN (1-1732): 0: 1630: 100.00		RAC3_HUMAN (32-206): 8.74e-75: 226: 56.00
+	Hs
		581101 MRCKA_HUMAN (1-1732): 0: 1630: 100.00		RAC2_HUMAN (32-216): 1.84e-74: 225: 52.43
+	Hs
		962148 MRCKA_HUMAN (1-1732): 0: 1630: 100.00		RHOA_HUMAN (33-215): 4.5e-74: 224: 42.62
+	Hs
		1015512 MRCKA_HUMAN (1-1732): 0: 1630: 100.00		RHOG_HUMAN (30-210): 9.78e-73: 221: 49.17
+	Hs
		955277 MRCKA_HUMAN (1-1732): 0: 1630: 100.00		CDC42_HUMAN (32-207): 2.13e-66: 205: 57.39
+	Hs
		1217563 MRCKA_HUMAN (1-1732): 0: 1630: 100.00		RHOJ_HUMAN (32-214): 8.34e-59: 186: 50.27
+	Hs
		1271069 MRCKB_HUMAN (1-1731): 0: 1429: 60.38		RHOU_HUMAN (32-236): 2.91e-89: 265: 60.48
+	Hs
		1396668 MRCKB_HUMAN (1-1731): 0: 1429: 60.38		RHOV_HUMAN (1-236): 1.28e-77: 235: 100.00
+	Hs
		988860 MRCKB_HUMAN (1-1731): 0: 1429: 60.38		RAC1_HUMAN (32-217): 7.38e-78: 234: 53.23
+	Hs
		601518 MRCKB_HUMAN (1-1731): 0: 1429: 60.38		RHOQ_HUMAN (23-236): 1.98e-75: 228: 50.00
+	Hs
		953780 MRCKB_HUMAN (1-1731): 0: 1429: 60.38		RAC3_HUMAN (32-206): 8.74e-75: 226: 56.00
+	Hs
		581399 MRCKB_HUMAN (1-1731): 0: 1429: 60.38		RAC2_HUMAN (32-216): 1.84e-74: 225: 52.43
+	Hs
		962678 MRCKB_HUMAN (1-1731): 0: 1429: 60.38		RHOA_HUMAN (33-215): 4.5e-74: 224: 42.62
+	Hs
		1015942 MRCKB_HUMAN (1-1731): 0: 1429: 60.38		RHOG_HUMAN (30-210): 9.78e-73: 221: 49.17
+	Hs
		955794 MRCKB_HUMAN (1-1731): 0: 1429: 60.38		CDC42_HUMAN (32-207): 2.13e-66: 205: 57.39
+	Hs
		1433601 MRCKB_HUMAN (1-1731): 0: 1429: 60.38		RHOJ_HUMAN (32-214): 8.34e-59: 186: 50.27
+	Hs
		601331 MRCKG_HUMAN (4-1712): 0: 1155: 40.31		RHOQ_HUMAN (23-236): 1.98e-75: 228: 50.00