HitPredict

Interactor 1: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (EC 3.6.5.2) (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Interactor 2: MRCKA (Q5VT25)
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)
Gene: CDC42BPA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0030027 - lamellipodium GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 1732
+	Hs
		988432 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		MRCKA_HUMAN (1-1732): 0: 1630: 100.00
+	Hs
		601324 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		MRCKA_HUMAN (1-1732): 0: 1630: 100.00
+	Hs
		988860 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		MRCKB_HUMAN (1-1731): 0: 1429: 60.38
+	Hs
		581399 RAC2_HUMAN (1-192): 1.14e-83: 247: 100.00		MRCKB_HUMAN (1-1731): 0: 1429: 60.38
+	Hs
		601518 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		MRCKB_HUMAN (1-1731): 0: 1429: 60.38
+	Hs
		988444 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		MRCKG_HUMAN (4-1712): 0: 1155: 40.31
+	Hs
		601331 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		MRCKG_HUMAN (4-1712): 0: 1155: 40.31
+	Hs
		157213 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		CTRO_HUMAN (4-1022): 3.08e-130: 453: 24.42
+	Hs
		988315 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		DMPK_HUMAN (1-539): 9.6e-141: 451: 48.17
+	Mm
		878598 RAC1_MOUSE (1-192): 3.43e-86: 253: 92.19		CTRO_MOUSE (4-1022): 4.89e-121: 425: 24.06
+	Hs
		728154 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		AKT1_HUMAN (13-407): 9.62e-129: 413: 31.02
+	Hs
		601185 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		AKT2_HUMAN (13-391): 2.77e-129: 414: 30.65
+	Hs
		270795 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		ROCK2_HUMAN (349-1052): 2.87e-23: 110: 13.87
+	Hs
		988339 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		ROCK1_HUMAN (372-1052): 2.32e-22: 107: 11.77
+	Dm
		828037 RAC1_DROME (1-192): 1.49e-83: 246: 89.06		Q9VXE3_DROME (349-1130): 1.86e-23: 111: 10.66
+	Hs
		270769 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		ROCK2_HUMAN (349-1052): 2.87e-23: 110: 13.87
+	Hs
		581026 RAC2_HUMAN (1-192): 1.14e-83: 247: 100.00		ROCK1_HUMAN (372-1052): 2.32e-22: 107: 11.77
+	Dm
		828045 RAC1_DROME (1-192): 1.49e-83: 246: 89.06		X2JE40_DROME (349-1111): 9.63e-23: 108: 10.93
+	Hs
		601274 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		ROCK1_HUMAN (372-1052): 2.32e-22: 107: 11.77
+	Hs
		270789 RAC3_HUMAN (1-191): 4.97e-80: 238: 89.01		ROCK2_HUMAN (349-1052): 2.87e-23: 110: 13.87