Protein: HEN2
Helix-loop-helix protein 2 (HEN-2) (Class A basic helix-loop-helix protein 34) (bHLHa34) (Nescient helix loop helix 2) (NSCL-2)

Gene: HEN2, NHLH2
Organism: Homo sapiens
Interactions: 29
UniProt ID: Q02577

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001223 - transcription coactivator binding
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

587057

ITF2
Transcription factor 4

4

20

High-throughput

0.890

High

1037919

HTF4
Transcription factor 12

4

20

High-throughput

0.890

High

587451

TFE2
Transcription factor E2-alpha

3

20

High-throughput

0.839

High

561211

MYF5
Myogenic factor 5

2

20

High-throughput

0.783

High

1037913

HES1
Transcription factor HES-1

1

20

Small-scale

0.724

High

832304

ID1
DNA-binding protein inhibitor ID-1

1

20

High-throughput

0.691

High

1037914

BHA15
Class A basic helix-loop-helix protein 15

1

18

High-throughput

0.691

High

126095

AP3B1
AP-3 complex subunit beta-1

2

0

High-throughput

0.576

High

1037925

KCIP1
A-type potassium channel modulatory protein KCNIP1

2

2

High-throughput

0.553

High

1037924

CUED1
CUE domain-containing protein 1

2

1

High-throughput

0.549

High

1037928

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

2

3

High-throughput

0.549

High

563646

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.541

High

1005846

GTF2I
General transcription factor II-I

1

0

High-throughput

0.513

High

698207

PDE4A
3',5'-cyclic-AMP phosphodiesterase 4A

1

1

High-throughput

0.489

High

895434

SPB8
Serpin B8

1

2

High-throughput

0.489

High

1037912

TF3C1
General transcription factor 3C polypeptide 1

1

1

High-throughput

0.489

High

1037916

CC71L
Coiled-coil domain-containing protein 71L

1

1

High-throughput

0.489

High

1037917

TF3C2
General transcription factor 3C polypeptide 2

1

1

High-throughput

0.489

High

1037921

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.489

High

1037927

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

3

High-throughput

0.489

High

1037918

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

5

Small-scale

0.479

High

883891

CENPF
Centromere protein F

1

3

High-throughput

0.445

High

1037920

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.445

High

911828

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

1

0

High-throughput

0.426

High

1037926

EXOG
Nuclease EXOG, mitochondrial

1

0

High-throughput

0.426

High

1037915

ARL10
ADP-ribosylation factor-like protein 10

1

1

High-throughput

0.407

High

1037922

TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

2

0

High-throughput

0.316

High

999342

HBB
Hemoglobin subunit beta

1

0

High-throughput

0.279

Low

1037923

TRPM3
Transient receptor potential cation channel subfamily M member 3

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025