HitPredict - High confidence protein-protein interactions

Interactor 1: HIF1A (Q61221)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein)
Gene: HIF1A

Interactor 2: SMAD3 (Q8BUN5)
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (mMad3) (SMAD family member 3) (SMAD 3) (Smad3)
Gene: SMAD3

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17053163
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001217 - DNA-binding transcription repressor activity GO:0001223 - transcription coactivator binding GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001666 - response to hypoxia GO:0001947 - heart looping and 18 others more... GO:0003677 - DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0005667 - transcription regulator complex GO:0005829 - cytosol GO:0006355 - regulation of DNA-templated transcription GO:0006915 - apoptotic process GO:0010629 - negative regulation of gene expression GO:0019901 - protein kinase binding GO:0030279 - negative regulation of ossification GO:0031625 - ubiquitin protein ligase binding GO:0032909 - regulation of transforming growth factor beta2 production GO:0043066 - negative regulation of apoptotic process GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0098586 - cellular response to virus GO:1902894 - negative regulation of miRNA transcription GO:1902895 - positive regulation of miRNA transcription
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	836
Mm

1	425

Service provided by Combinatics, Japan

Last updated: 11Aug2025