HitPredict

Interactor 1: ACVL1 (Q61288)
Activin receptor type-1-like (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (Serine/threonine-protein kinase receptor R3) (SKR3) (TGF-B superfamily receptor type I) (TSR-I)
Gene: Acvrl1

Interactor 2: GRAP (Q9CX99)
GRB2-related adapter protein
Gene: GRAP

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	24319055
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 502 Mm			1 217
+	Hs
		788891 TGFR2_HUMAN (79-493): 2.51e-114: 350: 32.15		GRB2_HUMAN (1-216): 2.42e-69: 212: 56.94
+	Hs
		463382 BMR1A_HUMAN (22-496): 2.76e-134: 400: 43.66		LYN_HUMAN (3-217): 2.3e-38: 140: 23.43
+	Hs
		932029 EPHB1_HUMAN (113-501): 8.85e-93: 305: 24.26		GRB2_HUMAN (1-216): 2.42e-69: 212: 56.94
+	Mm
		932044 EPHB2_MOUSE (95-501): 4.07e-91: 300: 23.40		GRB2_MOUSE (1-216): 1.6e-69: 213: 56.94
+	Hs
		710805 EPHB2_HUMAN (95-501): 7.39e-91: 300: 23.40		GRB2_HUMAN (1-216): 2.42e-69: 212: 56.94
+	Hs
		557291 BMPR2_HUMAN (40-501): 1.5e-100: 326: 29.30		SRC_HUMAN (2-217): 7.88e-41: 147: 24.27
+	Hs
		440502 ACVR1_HUMAN (10-500): 1.16e-133: 398: 58.55		FYN_HUMAN (162-216): 2.68e-11: 64.2: 28.07
+	Hs
		557121 EPHB2_HUMAN (95-501): 7.39e-91: 300: 23.40		SRC_HUMAN (2-217): 7.88e-41: 147: 24.27
+	Hs
		440419 TGFR2_HUMAN (79-493): 2.51e-114: 350: 32.15		FYN_HUMAN (162-216): 2.68e-11: 64.2: 28.07
+	Hs
		463009 TGFR2_HUMAN (79-493): 2.51e-114: 350: 32.15		YES_HUMAN (87-216): 7.59e-11: 62.7: 19.85
+	Hs
		593950 EPHB1_HUMAN (113-501): 8.85e-93: 305: 24.26		NCK1_HUMAN (5-145): 9.17e-24: 99: 36.05
+	Hs
		362174 EPHB2_HUMAN (95-501): 7.39e-91: 300: 23.40		ABL1_HUMAN (4-137): 6.71e-24: 100: 39.57
+	Hs
		710789 EPHB2_HUMAN (95-501): 7.39e-91: 300: 23.40		ABL2_HUMAN (4-137): 2.37e-23: 99.4: 38.85
+	Mm
		932042 EPHB2_MOUSE (95-501): 4.07e-91: 300: 23.40		ABL2_MOUSE (4-137): 7.67e-22: 95.1: 37.41
+	Hs
		710840 EPHB2_HUMAN (95-501): 7.39e-91: 300: 23.40		ITSN1_HUMAN (125-215): 7.01e-12: 66.2: 18.37
+	Mm
		431334 EPHB2_MOUSE (95-501): 4.07e-91: 300: 23.40		SRC_MOUSE (75-216): 8.86e-11: 62.7: 12.50
+	Hs
		462999 EPHB2_HUMAN (95-501): 7.39e-91: 300: 23.40		YES_HUMAN (87-216): 7.59e-11: 62.7: 19.85
+	Hs
		440580 AMHR2_HUMAN (187-496): 3.15e-35: 140: 32.53		FYN_HUMAN (162-216): 2.68e-11: 64.2: 28.07