HitPredict

Interactor 1: IRAK1 (Q62406)
Interleukin-1 receptor-associated kinase 1 (IRAK) (IRAK-1) (EC 2.7.11.1) (Pelle-like protein kinase) (mPLK)
Gene: IRAK1

Interactor 2: TLR9 (Q9EQU3)
Toll-like receptor 9 (CD antigen CD289)
Gene: TLR9

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	21911421
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_8~Pkinase
Common GO terms	GO:0005149 - interleukin-1 receptor binding GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0043410 - positive regulation of MAPK cascade GO:0045087 - innate immune response GO:0046330 - positive regulation of JNK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 710 Mm			1 1032
+	Hs
		905688 IRAK1_HUMAN (1-710): 0: 561: 80.79		TLR9_HUMAN (1-1032): 0: 562: 75.02
+	Mm
		1224133 IRAK1_MOUSE (1-710): 0: 615: 100.00		TLR4_MOUSE (53-617): 5.98e-32: 136: 19.49
+	At
		1490268 SERK2_ARATH (3-559): 4.09e-157: 470: 20.80		BRL2_ARATH (75-824): 1.16e-69: 255: 19.33
+	At
		88680 BAK1_ARATH (3-529): 3.61e-162: 482: 21.87		GSO1_ARATH (2-458): 6.82e-49: 191: 16.57
+	Hs
		252337 IRAK1_HUMAN (1-710): 0: 561: 80.79		TLR2_HUMAN (17-534): 5.42e-22: 104: 17.50
+	At
		1376472 BAK1_ARATH (3-529): 3.61e-162: 482: 21.87		FLS2_ARATH (379-858): 8.09e-45: 178: 17.29
+	At
		88676 NIK2_ARATH (3-569): 2.36e-156: 468: 18.80		GSO1_ARATH (2-458): 6.82e-49: 191: 16.57
+	Hs
		252278 IRAK1_HUMAN (1-710): 0: 561: 80.79		TLR5_HUMAN (450-876): 1.68e-18: 93.4: 15.88
+	Hs
		126299 IRAK1_HUMAN (1-710): 0: 561: 80.79		TLR4_HUMAN (2-483): 8.41e-18: 91.1: 17.47
+	At
		1426167 SERK4_ARATH (3-529): 3.11e-157: 470: 22.47		FLS2_ARATH (379-858): 8.09e-45: 178: 17.29
+	At
		1376479 BAK1_ARATH (3-529): 3.61e-162: 482: 21.87		BRL3_ARATH (4-369): 3.25e-40: 163: 16.97
+	At
		1376498 BAK1_ARATH (3-529): 3.61e-162: 482: 21.87		PEPR1_ARATH (10-448): 8.27e-39: 159: 16.43
+	At
		1441647 SERK4_ARATH (3-529): 3.11e-157: 470: 22.47		BRL3_ARATH (4-369): 3.25e-40: 163: 16.97
+	At
		88176 BAK1_ARATH (3-529): 3.61e-162: 482: 21.87		Y1743_ARATH (3-339): 3.13e-36: 150: 14.79
+	At
		1376476 BAK1_ARATH (3-529): 3.61e-162: 482: 21.87		PEPR2_ARATH (3-255): 2.35e-26: 119: 20.69
+	At
		88945 BAK1_ARATH (3-529): 3.61e-162: 482: 21.87		Y4361_ARATH (650-858): 5.44e-24: 111: 16.67
+	At
		1427617 SERK2_ARATH (3-559): 4.09e-157: 470: 20.80		PEPR2_ARATH (3-255): 2.35e-26: 119: 20.69
+	At
		1376505 BAK1_ARATH (3-529): 3.61e-162: 482: 21.87		BRL1_ARATH (550-810): 5.83e-21: 101: 17.23
+	At
		88963 SERK2_ARATH (3-559): 4.09e-157: 470: 20.80		Y4361_ARATH (650-858): 5.44e-24: 111: 16.67
+	At
		88930 F4I065_ARATH (10-550): 7.84e-151: 462: 20.47		Y4361_ARATH (650-858): 5.44e-24: 111: 16.67