Protein: TLR4
Toll-like receptor 4 (CD antigen CD284)

Gene: TLR4
Organism: Mus musculus
Interactions: 56
UniProt ID: Q9QUK6

Gene Ontology (top 5):
GO:0001530 - lipopolysaccharide binding
GO:0001726 - ruffle
GO:0001875 - lipopolysaccharide immune receptor activity
GO:0001891 - phagocytic cup
GO:0002218 - activation of innate immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1455798

TLR4
Toll-like receptor 4

4

17

Small-scale

0.873

High

648082

MYD88
Myeloid differentiation primary response protein MyD88

15

20

Small-scale

0.759

High

1224133

IRAK1
Interleukin-1 receptor-associated kinase 1

2

20

Small-scale

0.754

High

1440811

LY96
Lymphocyte antigen 96

5

2

Small-scale

0.726

High

1282026

TCAM1
TIR domain-containing adapter molecule 1

5

9

Small-scale

0.712

High

1221644

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

20

Small-scale

0.691

High

1296820

TCAM2
TIR domain-containing adapter molecule 2

4

8

Small-scale

0.674

High

1223492

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

18

Small-scale

0.665

High

1341614

IRAK4
Interleukin-1 receptor-associated kinase 4

1

20

Small-scale

0.665

High

1362363

SIG12
Sialic acid-binding Ig-like lectin 12

1

20

Small-scale

0.665

High

999895

TRAF6
TNF receptor-associated factor 6

3

11

Small-scale

0.650

High

431371

SRC
Proto-oncogene tyrosine-protein kinase Src

1

13

Small-scale

0.618

High

533127

CD14
Monocyte differentiation antigen CD14

1

20

Small-scale

0.618

High

869556

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

945956

ASM3B
Acid sphingomyelinase-like phosphodiesterase 3b

1

2

Small-scale

0.618

High

981425

RAB1A
Ras-related protein Rab-1A

1

3

Small-scale

0.618

High

1040015

KPCZ
Protein kinase C zeta type

1

6

Small-scale

0.618

High

1298779

C209B
CD209 antigen-like protein B

1

9

Small-scale

0.618

High

1455800

TBK1
Serine/threonine-protein kinase TBK1

1

6

Small-scale

0.618

High

661108

IRF8
Interferon regulatory factor 8

2

13

Small-scale

0.584

High

1455801

BCL10
B-cell lymphoma/leukemia 10

2

0

Small-scale

0.576

High

1245022

Q6PJ50
Sialic acid binding Ig-like lectin E

1

20

Small-scale

0.553

High

1362493

SIGL5
Sialic acid-binding Ig-like lectin 5

1

20

Small-scale

0.553

High

312516

NEMO
NF-kappa-B essential modulator

1

3

Small-scale

0.515

High

1221549

TRAF3
TNF receptor-associated factor 3

1

11

Small-scale

0.515

High

1223896

BIRC2
Baculoviral IAP repeat-containing protein 2

1

4

Small-scale

0.515

High

1189711

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

Small-scale

0.513

High

1424448

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

4

Small-scale

0.506

High

540228

FINC
Fibronectin

1

8

Small-scale

0.501

High

312671

BECN1
Beclin-1

1

0

Small-scale

0.493

High

957896

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

Small-scale

0.493

High

1408754

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

3

Small-scale

0.481

High

205333

NEUR1
Sialidase-1

1

3

Small-scale

0.479

High

456930

ANXA2
Annexin A2

1

1

Small-scale

0.479

High

604532

SPI1
Transcription factor PU.1

1

5

Small-scale

0.479

High

890929

CAV1
Caveolin-1

1

1

Small-scale

0.479

High

989289

HSP7C
Heat shock cognate 71 kDa protein

1

7

Small-scale

0.479

High

989465

CH60
60 kDa heat shock protein, mitochondrial

1

6

Small-scale

0.479

High

991158

HMGB1
High mobility group protein B1

1

5

Small-scale

0.479

High

1021423

AMPN
Aminopeptidase N

1

1

Small-scale

0.479

High

1189205

STING
Stimulator of interferon genes protein

1

2

High-throughput

0.479

High

1225445

IRF4
Interferon regulatory factor 4

1

13

Small-scale

0.479

High

1283214

NANOG
Homeobox protein NANOG

1

1

High-throughput

0.479

High

1297239

CNPY4
Protein canopy homolog 4

1

13

Small-scale

0.479

High

1317137

I17RD
Interleukin-17 receptor D

1

1

Small-scale

0.479

High

148451

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

Small-scale

0.470

High

690069

S10A8
Protein S100-A8

1

0

Small-scale

0.458

High

715015

FETUA
Alpha-2-HS-glycoprotein

1

1

Small-scale

0.457

High

205666

PK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

1

2

Small-scale

0.445

High

834260

MMP9
Matrix metalloproteinase-9

1

3

Small-scale

0.437

High

1064410

EPS8
Epidermal growth factor receptor kinase substrate 8

1

8

Small-scale

0.437

High

1423956

RN115
E3 ubiquitin-protein ligase RNF115

1

5

Small-scale

0.437

High

1424178

Q9DAD3
WD repeat and FYVE domain containing 1

1

2

Small-scale

0.437

High

1455799

CHIP
E3 ubiquitin-protein ligase CHIP

1

6

Small-scale

0.437

High

1189599

CBLB
E3 ubiquitin-protein ligase CBL-B

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025