HitPredict

Interactor 1: SMAD2 (Q62432)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (Mad-related protein 2) (mMad2) (SMAD family member 2) (SMAD 2) (Smad2)
Gene: SMAD2

Interactor 2: ITCH (Q8C863)
E3 ubiquitin-protein ligase Itchy (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase Itchy homolog)
Gene: ITCH

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	15350225
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, ubiquitination reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 467 Mm			1 864
+	Hs
		1153872 SMAD2_HUMAN (1-467): 0: 679: 99.57		ITCH_HUMAN (1-864): 0: 904: 91.27
+	Hs
		1014581 SMAD3_HUMAN (1-467): 0: 621: 83.94		ITCH_HUMAN (1-864): 0: 904: 91.27
+	Hs
		1153902 SMAD2_HUMAN (1-467): 0: 679: 99.57		WWP1_HUMAN (1-864): 0: 832: 57.65
+	Hs
		132068 SMAD2_HUMAN (1-467): 0: 679: 99.57		WWP2_HUMAN (1-864): 0: 831: 55.78
+	Hs
		1153877 SMAD2_HUMAN (1-467): 0: 679: 99.57		NED4L_HUMAN (1-861): 0: 790: 32.68
+	Hs
		1014611 SMAD3_HUMAN (1-467): 0: 621: 83.94		WWP1_HUMAN (1-864): 0: 832: 57.65
+	Hs
		131948 SMAD3_HUMAN (1-467): 0: 621: 83.94		WWP2_HUMAN (1-864): 0: 831: 55.78
+	Hs
		1014582 SMAD3_HUMAN (1-467): 0: 621: 83.94		NED4L_HUMAN (1-861): 0: 790: 32.68
+	Hs
		1406689 SMAD5_HUMAN (1-467): 0: 579: 55.45		WWP1_HUMAN (1-864): 0: 832: 57.65
+	Hs
		861618 SMAD2_HUMAN (1-467): 0: 679: 99.57		NEDD4_HUMAN (90-861): 0: 720: 35.39
+	Dm
		837198 MAD_DROME (1-467): 0: 595: 55.90		SUDX_DROME (14-864): 0: 800: 48.63
+	Hs
		861565 SMAD3_HUMAN (1-467): 0: 621: 83.94		NEDD4_HUMAN (90-861): 0: 720: 35.39
+	Hs
		861742 SMAD5_HUMAN (1-467): 0: 579: 55.45		NEDD4_HUMAN (90-861): 0: 720: 35.39
+	Hs
		1153916 SMAD2_HUMAN (1-467): 0: 679: 99.57		SMUF2_HUMAN (1-354): 4.62e-46: 178: 22.43
+	Hs
		1153920 SMAD2_HUMAN (1-467): 0: 679: 99.57		SMUF1_HUMAN (1-475): 1.36e-41: 165: 15.39
+	Hs
		1014620 SMAD3_HUMAN (1-467): 0: 621: 83.94		SMUF2_HUMAN (1-354): 4.62e-46: 178: 22.43
+	Hs
		1014624 SMAD3_HUMAN (1-467): 0: 621: 83.94		SMUF1_HUMAN (1-475): 1.36e-41: 165: 15.39
+	Hs
		1406694 SMAD5_HUMAN (1-467): 0: 579: 55.45		SMUF2_HUMAN (1-354): 4.62e-46: 178: 22.43
+	Xl
		1009592 P79947_XENLA (1-467): 0: 581: 55.64		SMUF1_XENLA (1-470): 4.05e-36: 148: 15.26
+	Dm
		837159 MAD_DROME (1-467): 0: 595: 55.90		SMUF1_DROME (16-393): 3.23e-27: 121: 14.69