HitPredict

Interactor 1: TIF1A (Q64127)
Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase Trim24) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24)
Gene: Trim24

Interactor 2: Q9DCC5 (Q9DCC5)
Cbx3 protein (Chromobox 3)
Gene: Cbx3

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	10562550
Identification Methods	pull down, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Chromo~PHD
Common GO terms	GO:0000791 - euchromatin GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1051 Mm			1 183
+	Hs
		180803 TIF1A_HUMAN (1-1051): 0: 594: 92.80		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Mm
		1223214 TIF1A_MOUSE (1-1051): 0: 620: 100.00		CBX5_MOUSE (11-182): 1.22e-55: 175: 59.89
+	Mm
		1014254 TIF1A_MOUSE (1-1051): 0: 620: 100.00		CBX1_MOUSE (36-180): 1.03e-53: 170: 71.33
+	Hs
		180744 TIF1A_HUMAN (1-1051): 0: 594: 92.80		CBX5_HUMAN (11-182): 1.63e-55: 175: 59.89
+	Hs
		180780 TIF1A_HUMAN (1-1051): 0: 594: 92.80		CBX1_HUMAN (36-180): 1.03e-53: 170: 71.33
+	Hs
		1097632 TRI33_HUMAN (49-1051): 6.96e-160: 504: 45.66		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		180931 TIF1A_HUMAN (1-1051): 0: 594: 92.80		CBX8_HUMAN (21-116): 2.35e-26: 104: 32.00
+	Hs
		1014232 TRI33_HUMAN (49-1051): 6.96e-160: 504: 45.66		CBX1_HUMAN (36-180): 1.03e-53: 170: 71.33
+	Hs
		1438670 TRI33_HUMAN (49-1051): 6.96e-160: 504: 45.66		CBX8_HUMAN (21-116): 2.35e-26: 104: 32.00
+	Dm
		426754 Q9VDK5_DROME (9-1025): 1.08e-107: 364: 21.22		HP1_DROME (9-180): 2.13e-45: 150: 38.73
+	Dm
		72163 A8WHL4_DROME (9-1025): 1.4e-104: 355: 21.26		HP1_DROME (9-180): 2.13e-45: 150: 38.73
+	Hs
		623279 RO52_HUMAN (123-500): 2.58e-62: 222: 13.06		CBX1_HUMAN (36-180): 1.03e-53: 170: 71.33
+	Hs
		853414 TRI39_HUMAN (118-385): 1.37e-59: 215: 15.13		CBX5_HUMAN (11-182): 1.63e-55: 175: 59.89
+	Hs
		216382 PML_HUMAN (13-599): 1.06e-57: 217: 17.43		SUV91_HUMAN (3-179): 4.75e-40: 141: 16.20
+	Hs
		216442 Q15156_HUMAN (13-396): 2.06e-58: 217: 19.30		SUV91_HUMAN (3-179): 4.75e-40: 141: 16.20
+	Hs
		1438663 TRIM1_HUMAN (26-464): 2.44e-70: 251: 15.51		CBX8_HUMAN (21-116): 2.35e-26: 104: 32.00
+	Hs
		129650 RO52_HUMAN (123-500): 2.58e-62: 222: 13.06		CBX4_HUMAN (21-121): 4.97e-27: 108: 29.52
+	Hs
		129664 PML_HUMAN (13-599): 1.06e-57: 217: 17.43		CBX4_HUMAN (21-121): 4.97e-27: 108: 29.52
+	Hs
		338849 LIN41_HUMAN (62-430): 6.61e-58: 217: 19.21		CBX6_HUMAN (21-124): 3.32e-27: 107: 27.78
+	Hs
		783421 TRI23_HUMAN (28-402): 1.5e-59: 216: 14.68		CBX8_HUMAN (21-116): 2.35e-26: 104: 32.00