HitPredict

Interactor 1: TOP2B (Q64511)
DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)
Gene: TOP2B

Interactor 2: UHRF1 (Q8VDF2)
E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (RING-type E3 ubiquitin transferase UHRF1) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (mUhrf1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)
Gene: UHRF1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25451918
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1612 Mm			1 782
+	Mm
		1225762 TOP2B_MOUSE (1-1612): 0: 1786: 100.00		UHRF2_MOUSE (1-782): 0: 839: 52.32
+	Mm
		1030128 TOP2A_MOUSE (25-1600): 0: 1610: 65.06		UHRF1_MOUSE (1-782): 0: 932: 100.00
+	Hs
		542623 TOP2A_HUMAN (26-1604): 0: 1604: 65.49		UHRF1_HUMAN (1-782): 0: 889: 72.94
+	Mm
		1030122 TOP2A_MOUSE (25-1600): 0: 1610: 65.06		UHRF2_MOUSE (1-782): 0: 839: 52.32
+	Hs
		1039487 TOP2B_HUMAN (13-1612): 0: 1731: 95.96		CHD3_HUMAN (209-507): 5.36e-54: 205: 16.67
+	Hs
		1039499 TOP2B_HUMAN (13-1612): 0: 1731: 95.96		CHD4_HUMAN (260-507): 1.33e-45: 179: 16.17
+	Hs
		542487 TOP2A_HUMAN (26-1604): 0: 1604: 65.49		CHD3_HUMAN (209-507): 5.36e-54: 205: 16.67
+	Hs
		542516 TOP2A_HUMAN (26-1604): 0: 1604: 65.49		CHD4_HUMAN (260-507): 1.33e-45: 179: 16.17
+	Dm
		356713 TOP2_DROME (31-1398): 0: 1473: 54.75		CHDM_DROME (260-500): 2.1e-38: 156: 13.64
+	Dm
		356850 Q9VGW4_DROME (1067-1609): 1.16e-16: 88.8: 9.52		CHDM_DROME (260-500): 2.1e-38: 156: 13.64
+	Dm
		356890 Q9VPR2_DROME (1189-1583): 6.76e-12: 72.6: 14.89		CHDM_DROME (260-500): 2.1e-38: 156: 13.64