Protein: TOP2A
DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)

Gene: TOP2A
Organism: Mus musculus
Interactions: 34
UniProt ID: Q01320

Gene Ontology (top 5):
GO:0000228 - nuclear chromosome
GO:0000287 - magnesium ion binding
GO:0000775 - chromosome, centromeric region
GO:0000793 - condensed chromosome
GO:0001673 - male germ cell nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

629242

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.536

High

60005

ARI1A
AT-rich interactive domain-containing protein 1A

1

4

Small-scale

0.500

High

236726

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

4

Small-scale

0.500

High

1021770

SMRC1
SWI/SNF complex subunit SMARCC1

1

3

Small-scale

0.500

High

1030114

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

11

Small-scale

0.500

High

1030119

REQU
Zinc finger protein ubi-d4

1

8

Small-scale

0.500

High

1030120

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

2

Small-scale

0.500

High

1030121

SSXT
Protein SSXT

1

3

Small-scale

0.500

High

1030125

PB1
Protein polybromo-1

1

17

Small-scale

0.500

High

1030133

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

Small-scale

0.500

High

876523

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C]

1

5

Small-scale

0.479

High

921238

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

Small-scale

0.479

High

989548

MK01
Mitogen-activated protein kinase 1

1

2

Small-scale

0.479

High

1030116

TET2
Methylcytosine dioxygenase TET2

1

1

Small-scale

0.479

High

1030122

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

11

Small-scale

0.479

High

1030123

FACD2
Fanconi anemia group D2 protein homolog

1

3

High-throughput

0.479

High

1030124

NANOG
Homeobox protein NANOG

1

1

High-throughput

0.479

High

1030127

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.479

High

1030128

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

10

Small-scale

0.479

High

1030130

RBP2
E3 SUMO-protein ligase RanBP2

1

4

Small-scale

0.479

High

1030131

CUL3
Cullin-3

1

4

Small-scale

0.479

High

927733

ATX1
Ataxin-1

1

0

High-throughput

0.458

High

1030115

Q3UQ17
Zinc finger and BTB domain containing 16

1

0

Small-scale

0.458

High

1030117

CLU
Clustered mitochondria protein homolog

1

0

High-throughput

0.458

High

1030118

Q5SXC4
Vascular endothelial zinc finger 1

1

0

Small-scale

0.458

High

1030129

ATG5
Autophagy protein 5

1

0

Small-scale

0.458

High

1030134

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

1

High-throughput

0.457

High

98007

ARI1B
AT-rich interactive domain-containing protein 1B

1

3

Small-scale

0.445

High

555573

NR4A1
Nuclear receptor subfamily 4 group A member 1

1

7

Small-scale

0.445

High

883762

CENPC
Centromere protein C

1

3

High-throughput

0.445

High

915546

HMGA2
High mobility group protein HMGI-C

1

2

High-throughput

0.445

High

1030132

AIRE
Autoimmune regulator

1

9

Small-scale

0.445

High

1030126

ARRB1
Beta-arrestin-1

1

0

High-throughput

0.438

High

1030113

STING
Stimulator of interferon genes protein

1

0

High-throughput

0.426

High


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Last updated: 11Aug2025