Protein: SYLM
Leucine--tRNA ligase, mitochondrial (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)

Gene: SYLM, LARS2
Organism: Homo sapiens
Interactions: 136
UniProt ID: Q15031

Gene Ontology (top 5):
GO:0002161 - aminoacyl-tRNA editing activity
GO:0004823 - leucine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

726209

BASI
Basigin

3

1

High-throughput

0.667

High

258704

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

2

High-throughput

0.628

High

1064924

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

2

1

High-throughput

0.628

High

1064931

RM21
Large ribosomal subunit protein bL21m

2

1

High-throughput

0.628

High

1064923

MRM1
rRNA methyltransferase 1, mitochondrial

2

2

High-throughput

0.611

High

1064964

MTG2
Mitochondrial ribosome-associated GTPase 2

2

5

High-throughput

0.611

High

671070

ATPD
ATP synthase subunit delta, mitochondrial

2

0

High-throughput

0.602

High

790249

THIM
3-ketoacyl-CoA thiolase, mitochondrial

2

0

High-throughput

0.602

High

862995

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

2

0

High-throughput

0.602

High

1064932

NIT1
Deaminated glutathione amidase

2

0

High-throughput

0.602

High

227489

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

262817

CISY
Citrate synthase, mitochondrial

2

2

High-throughput

0.584

High

1064918

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

2

High-throughput

0.584

High

326319

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

2

1

High-throughput

0.574

High

885861

YBEY
Endoribonuclease YbeY

2

1

High-throughput

0.574

High

1064970

DUS22
Dual specificity protein phosphatase 22

2

2

High-throughput

0.574

High

205409

TGON2
Trans-Golgi network integral membrane protein 2

2

1

High-throughput

0.558

High

646401

KAD4
Adenylate kinase 4, mitochondrial

1

2

High-throughput

0.536

High

815368

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

2

High-throughput

0.536

High

1064933

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

1064936

CBR4
3-oxoacyl-[acyl-carrier-protein] reductase

1

1

High-throughput

0.536

High

1064940

DHB8
(3R)-3-hydroxyacyl-CoA dehydrogenase

1

1

High-throughput

0.536

High

1064949

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

1

High-throughput

0.536

High

1064950

RT24
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.536

High

1064983

AMACR
Alpha-methylacyl-CoA racemase

1

1

High-throughput

0.536

High

1064988

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

1064989

RT02
Small ribosomal subunit protein uS2m

1

4

High-throughput

0.536

High

1064919

HKDC1
Hexokinase HKDC1

1

1

High-throughput

0.515

High

254699

PTCD1
Pentatricopeptide repeat-containing protein 1, mitochondrial

1

0

High-throughput

0.513

High

270921

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

0

High-throughput

0.513

High

272350

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.513

High

311237

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

0

High-throughput

0.513

High

398354

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

0

High-throughput

0.513

High

602101

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

High-throughput

0.513

High

602398

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

1

0

High-throughput

0.513

High

836732

DNLI3
DNA ligase 3

1

0

High-throughput

0.513

High

1064917

TAZ
Tafazzin

1

0

High-throughput

0.513

High

1064927

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

0

High-throughput

0.513

High

1064934

ETKMT
Electron transfer flavoprotein beta subunit lysine methyltransferase

1

0

High-throughput

0.513

High

1064957

MYL10
Myosin regulatory light chain 10

1

0

High-throughput

0.513

High

1064969

RT30
Large ribosomal subunit protein mL65

1

0

High-throughput

0.513

High

1064971

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

High-throughput

0.513

High

1064976

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

0

High-throughput

0.513

High

1064977

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

0

High-throughput

0.513

High

1064980

NPS3A
Protein NipSnap homolog 3A

1

0

High-throughput

0.513

High

1064984

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.513

High

1064986

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.513

High

1064987

RT07
Small ribosomal subunit protein uS7m

1

0

High-throughput

0.513

High

146345

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

1

High-throughput

0.489

High

171998

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.489

High

719717

RADI
Radixin

1

1

High-throughput

0.489

High

1064938

SRB4D
Scavenger receptor cysteine-rich domain-containing group B protein

1

1

High-throughput

0.489

High

1064954

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.489

High

1064955

LSMD1
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

1

High-throughput

0.489

High

1064968

B2L12
Bcl-2-like protein 12

1

1

High-throughput

0.489

High

1064991

WIF1
Wnt inhibitory factor 1

1

1

High-throughput

0.489

High

1064993

NPTN
Neuroplastin

1

1

High-throughput

0.489

High

59184

VWA8
von Willebrand factor A domain-containing protein 8

1

2

High-throughput

0.479

High

173032

RT12
Small ribosomal subunit protein uS12m

1

3

High-throughput

0.479

High

264907

MPPB
Mitochondrial-processing peptidase subunit beta

1

5

High-throughput

0.479

High

270036

RF1M
Peptide chain release factor 1, mitochondrial

1

9

High-throughput

0.479

High

327438

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

3

High-throughput

0.479

High

336870

OTC
Ornithine transcarbamylase, mitochondrial

1

3

High-throughput

0.479

High

384867

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.479

High

440519

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

3

High-throughput

0.479

High

486526

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

2

High-throughput

0.479

High

499757

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.479

High

525508

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

2

High-throughput

0.479

High

777566

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

789796

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.479

High

799226

EFTS
Elongation factor Ts, mitochondrial

1

2

High-throughput

0.479

High

803115

IF2M
Translation initiation factor IF-2, mitochondrial

1

10

High-throughput

0.479

High

827388

EFTU
Elongation factor Tu, mitochondrial

1

11

High-throughput

0.479

High

827944

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

High-throughput

0.479

High

981250

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

990065

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

High-throughput

0.479

High

1014371

MPPA
Mitochondrial-processing peptidase subunit alpha

1

5

High-throughput

0.479

High

1017895

GRSF1
G-rich sequence factor 1

1

4

High-throughput

0.479

High

1020426

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

7

High-throughput

0.479

High

1045756

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

2

High-throughput

0.479

High

1050954

ICT1
Large ribosomal subunit protein mL62

1

2

High-throughput

0.479

High

1062226

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

9

High-throughput

0.479

High

1064915

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.479

High

1064916

SURF1
Surfeit locus protein 1

1

2

High-throughput

0.479

High

1064920

SYAM
Alanine--tRNA ligase, mitochondrial

1

3

High-throughput

0.479

High

1064925

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

5

High-throughput

0.479

High

1064930

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

9

High-throughput

0.479

High

1064941

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

7

High-throughput

0.479

High

1064942

FAKD4
FAST kinase domain-containing protein 4

1

9

High-throughput

0.479

High

1064943

MCUR1
Mitochondrial calcium uniporter regulator 1

1

5

High-throughput

0.479

High

1064945

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

5

High-throughput

0.479

High

1064947

RRFM
Ribosome-recycling factor, mitochondrial

1

2

High-throughput

0.479

High

1064948

MTEF3
Transcription termination factor 3, mitochondrial

1

2

High-throughput

0.479

High

1064951

EFGM
Elongation factor G, mitochondrial

1

7

High-throughput

0.479

High

1064956

TACO1
Translational activator of cytochrome c oxidase 1

1

2

High-throughput

0.479

High

1064958

TR61B
tRNA

1

2

High-throughput

0.479

High

1064959

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

3

High-throughput

0.479

High

1064960

RT26
Small ribosomal subunit protein mS26

1

2

High-throughput

0.479

High

1064961

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

5

High-throughput

0.479

High

1064962

IF3M
Translation initiation factor IF-3, mitochondrial

1

2

High-throughput

0.479

High

1064963

MTRFR
Mitochondrial translation release factor in rescue

1

9

High-throughput

0.479

High

1064966

MET17
Ribosome assembly protein METTL17, mitochondrial

1

2

High-throughput

0.479

High

1064967

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

2

High-throughput

0.479

High

1064972

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

4

High-throughput

0.479

High

1064973

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

3

High-throughput

0.479

High

1064974

RMND1
Required for meiotic nuclear division protein 1 homolog

1

2

High-throughput

0.479

High

1064978

MRES1
Mitochondrial transcription rescue factor 1

1

2

High-throughput

0.479

High

1064981

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

9

High-throughput

0.479

High

1064990

RM11
Large ribosomal subunit protein uL11m

1

3

High-throughput

0.479

High

646904

1433T
14-3-3 protein theta

1

4

High-throughput

0.457

High

1064929

RHOU
Rho-related GTP-binding protein RhoU

1

4

High-throughput

0.457

High

1064921

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

552763

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

651244

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

720504

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

951005

RHOG
Rho-related GTP-binding protein RhoG

1

3

High-throughput

0.437

High

994492

QOR
Quinone oxidoreductase

1

4

High-throughput

0.437

High

1064926

CH082
UPF0598 protein C8orf82

1

2

High-throughput

0.437

High

1064928

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

1064946

OPTN
Optineurin

1

6

High-throughput

0.437

High

1064953

IMP2L
Mitochondrial inner membrane protease subunit 2

1

4

High-throughput

0.437

High

1064965

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

1064982

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

1064985

FBW1B
F-box/WD repeat-containing protein 11

1

4

High-throughput

0.437

High

1064975

TRM1
tRNA

1

1

High-throughput

0.407

High

1064939

GLMP
Glycosylated lysosomal membrane protein

2

0

High-throughput

0.328

High

245233

RAMP2
Receptor activity-modifying protein 2

1

0

High-throughput

0.279

Low

542520

QCR7
Cytochrome b-c1 complex subunit 7

1

0

High-throughput

0.279

Low

1064922

SYT6
Synaptotagmin-6

1

0

High-throughput

0.279

Low

1064944

TRI43
Tripartite motif-containing protein 43

1

0

High-throughput

0.279

Low

1064952

RSLAB
Ras-like protein family member 10B

1

0

High-throughput

0.279

Low

1064979

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1064992

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

1035440

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.249

Low

1064935

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1064937

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024