HitPredict

Interactor 1: H2A2C (Q64523)
Histone H2A type 2-C (H2A-clustered histone 20) (H2a-613B)
Gene: H2ac20

Interactor 2: CHFR (Q810L3)
E3 ubiquitin-protein ligase CHFR (EC 2.3.2.27) (Checkpoint with forkhead and RING finger domains protein) (RING-type E3 ubiquitin transferase CHFR)
Gene: CHFR

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21706008
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 129 Mm			1 664
+	Hs
		302541 H2A2C_HUMAN (1-129): 7.14e-67: 199: 100.00		RNF8_HUMAN (19-386): 1.85e-107: 335: 19.40
+	Hs
		302313 H2A1B_HUMAN (1-127): 8.33e-65: 194: 94.49		RNF8_HUMAN (19-386): 1.85e-107: 335: 19.40
+	Mm
		1225791 H2A2C_MOUSE (1-129): 7.14e-67: 199: 100.00		RNF8_MOUSE (19-385): 5.97e-105: 329: 17.83
+	Hs
		302361 H2AX_HUMAN (1-123): 7.41e-64: 192: 95.12		RNF8_HUMAN (19-386): 1.85e-107: 335: 19.40
+	Hs
		765566 H2A2C_HUMAN (1-129): 7.14e-67: 199: 100.00		BMI1_HUMAN (286-465): 1.5e-41: 155: 18.09
+	Hs
		1162876 H2A2C_HUMAN (1-129): 7.14e-67: 199: 100.00		RING2_HUMAN (273-468): 3.35e-40: 152: 14.95
+	Hs
		1307302 H2A2B_HUMAN (1-126): 2.41e-66: 198: 96.83		RING2_HUMAN (273-468): 3.35e-40: 152: 14.95
+	Hs
		502255 H2A1_HUMAN (1-127): 5.37e-65: 195: 96.06		BMI1_HUMAN (286-465): 1.5e-41: 155: 18.09
+	Hs
		765622 H2A2A_HUMAN (1-127): 3.39e-65: 195: 97.64		BMI1_HUMAN (286-465): 1.5e-41: 155: 18.09
+	Hs
		418858 H2A1B_HUMAN (1-127): 8.33e-65: 194: 94.49		BMI1_HUMAN (286-465): 1.5e-41: 155: 18.09
+	Hs
		1232718 H2A2A_HUMAN (1-127): 3.39e-65: 195: 97.64		RING2_HUMAN (273-468): 3.35e-40: 152: 14.95
+	Hs
		1272814 H2A3_HUMAN (1-127): 5.37e-65: 195: 95.28		RING2_HUMAN (273-468): 3.35e-40: 152: 14.95
+	Hs
		502492 H2A1_HUMAN (1-127): 5.37e-65: 195: 96.06		RING2_HUMAN (273-468): 3.35e-40: 152: 14.95
+	Hs
		591506 H2AX_HUMAN (1-123): 7.41e-64: 192: 95.12		BMI1_HUMAN (286-465): 1.5e-41: 155: 18.09
+	Hs
		419154 H2A1B_HUMAN (1-127): 8.33e-65: 194: 94.49		RING2_HUMAN (273-468): 3.35e-40: 152: 14.95
+	Hs
		418952 H2A1B_HUMAN (1-127): 8.33e-65: 194: 94.49		RING1_HUMAN (267-462): 2.47e-39: 151: 16.19
+	Hs
		591803 H2AX_HUMAN (1-123): 7.41e-64: 192: 95.12		RING2_HUMAN (273-468): 3.35e-40: 152: 14.95
+	Hs
		591610 H2AX_HUMAN (1-123): 7.41e-64: 192: 95.12		RING1_HUMAN (267-462): 2.47e-39: 151: 16.19
+	Hs
		502512 H2A1_HUMAN (1-127): 5.37e-65: 195: 96.06		PCGF1_HUMAN (286-443): 2.92e-35: 135: 17.68
+	Hs
		419178 H2A1B_HUMAN (1-127): 8.33e-65: 194: 94.49		PCGF1_HUMAN (286-443): 2.92e-35: 135: 17.68