Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: ACE2 (Q9BYF1)
Angiotensin-converting enzyme 2 (EC 3.4.17.23) (Angiotensin-converting enzyme homolog) (ACEH) (Angiotensin-converting enzyme-related carboxypeptidase) (ACE-related carboxypeptidase) (EC 3.4.17.-) (Metalloprotease MPROT15) [Cleaved into: Processed angiotensin-converting enzyme 2]
Gene: ACE2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 0.60 0.708

The method score is based on:

Property Details
Experiments 33965375, 36057605, 36584595, 34615619
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, pull down, proximity ligation assay, cross-linking study
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005788 - endoplasmic reticulum lumen
GO:0005886 - plasma membrane
GO:0009986 - cell surface
GO:0016020 - membrane
GO:0070062 - extracellular exosome
Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 654
Hs

1 805
+ Hs
+ Hs

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Last updated: 15 Jul 2024