HitPredict

Interactor 1: K1C40 (Q6A162)
Keratin, type I cytoskeletal 40 (Cytokeratin-40) (CK-40) (Keratin-40) (K40) (Type I hair keratin Ka36)
Gene: KRT40

Interactor 2: UACA (Q9BZF9)
Uveal autoantigen with coiled-coil domains and ankyrin repeats
Gene: UACA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	25416956
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 431 Hs			1 1416
+	Hs
		300527 KRT34_HUMAN (29-430): 8.4e-153: 440: 62.53		KDIS_HUMAN (1-203): 2.26e-43: 175: 25.24
+	Hs
		67555 K1C39_HUMAN (2-430): 3.24e-153: 444: 50.11		MYH7B_HUMAN (295-1350): 1.65e-35: 150: 13.75
+	Mm
		59655 K2C5_MOUSE (60-411): 1.57e-146: 430: 26.33		A2AM57_MOUSE (32-260): 1.58e-10: 68.2: 27.27
+	Hs
		49879 A1A4E9_HUMAN (80-411): 7.53e-95: 294: 50.75		MYH1_HUMAN (238-1321): 1.33e-35: 150: 11.96
+	Hs
		556836 K1C13_HUMAN (80-411): 1.73e-94: 293: 50.75		MYH1_HUMAN (238-1321): 1.33e-35: 150: 11.96
+	Hs
		1230326 K1C40_HUMAN (1-431): 7.72e-82: 260: 100.00		MYH4_HUMAN (346-1265): 1.58e-36: 153: 12.46
+	Hs
		556859 K1C40_HUMAN (1-431): 7.72e-82: 260: 100.00		MYH1_HUMAN (238-1321): 1.33e-35: 150: 11.96
+	Hs
		563058 K1C40_HUMAN (1-431): 7.72e-82: 260: 100.00		MYH8_HUMAN (238-1321): 4.03e-35: 148: 11.87
+	Hs
		556936 K1C40_HUMAN (1-431): 7.72e-82: 260: 100.00		MYH7_HUMAN (347-1236): 5.04e-34: 145: 12.04
+	Hs
		1146150 K1H1_HUMAN (44-425): 1.31e-72: 235: 62.57		UACA_HUMAN (2-1259): 4.82e-34: 145: 12.72
+	Hs
		1230311 K1C40_HUMAN (1-431): 7.72e-82: 260: 100.00		MYH2_HUMAN (322-1076): 2.31e-23: 110: 10.68
+	Hs
		300847 KRT38_HUMAN (1-430): 1.74e-74: 241: 49.30		RAI14_HUMAN (987-1410): 1.87e-29: 129: 32.55
+	Mm
		59630 K1C14_MOUSE (88-400): 3.04e-95: 296: 52.72		A2AM57_MOUSE (32-260): 1.58e-10: 68.2: 27.27
+	Mm
		59629 K1C15_MOUSE (84-401): 6.41e-94: 291: 49.84		A2AM57_MOUSE (32-260): 1.58e-10: 68.2: 27.27
+	Hs
		535943 K1C40_HUMAN (1-431): 7.72e-82: 260: 100.00		MYH3_HUMAN (300-989): 3.65e-18: 93.4: 12.21
+	Mm
		59635 K2C73_MOUSE (1-403): 1.52e-83: 267: 24.39		A2AM57_MOUSE (32-260): 1.58e-10: 68.2: 27.27
+	Hs
		300720 KRT38_HUMAN (1-430): 1.74e-74: 241: 49.30		POTEI_HUMAN (27-156): 3.34e-16: 86.5: 23.88
+	Mm
		59587 K2C6A_MOUSE (57-416): 6.43e-77: 250: 25.75		A2AM57_MOUSE (32-260): 1.58e-10: 68.2: 27.27
+	Mm
		59650 K2C79_MOUSE (26-423): 1.32e-76: 249: 25.25		A2AM57_MOUSE (32-260): 1.58e-10: 68.2: 27.27
+	Mm
		59634 K1C42_MOUSE (6-425): 1.9e-73: 238: 45.24		A2AM57_MOUSE (32-260): 1.58e-10: 68.2: 27.27