Interactor 1: LRC8B (Q6P9F7)
Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP)
Gene: LRRC8B
Interactor 2: LRC8A (Q8IWT6)
Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A) (HsLRRC8A) (Swelling protein 1)
Gene: LRRC8A
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.84 | 1.00 | 0.919 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 28514442, 33961781, 40437099, 24790029, unassigned3799 |
| Identification Methods | affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation |
| Interaction Type | physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | LRR_5~LRR_8, LRR_8~LRR_8, Pannexin_like~Pannexin_like |
| Common GO terms | GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0015810 - aspartate transmembrane transport GO:0034702 - monoatomic ion channel complex GO:0035556 - intracellular signal transduction and 2 others more... |
| Homologous interactions | 13 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
